8STN
Crystal structure of KRAS-G12D/G75A mutant, GDP-bound
Summary for 8STN
Entry DOI | 10.2210/pdb8stn/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | kras, ras, nucleotide-binding protein, signaling protein, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 39830.65 |
Authors | Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2023-05-10, release date: 2023-08-23, Last modification date: 2023-10-11) |
Primary citation | Yang, M.H.,Tran, T.H.,Hunt, B.,Agnor, R.,Johnson, C.W.,Shui, B.,Waybright, T.J.,Nowak, J.A.,Stephen, A.G.,Simanshu, D.K.,Haigis, K.M. Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity. Cancer Res., 83:3176-3183, 2023 Cited by PubMed: 37556505DOI: 10.1158/0008-5472.CAN-22-3210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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