8STM

Crystal structure of KRAS-G75A mutant, GDP-bound

Summary for 8STM

Entry DOI	10.2210/pdb8stm/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	kras, ras, nucleotide-binding protein, signaling protein, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	79241.37
Authors	Tran, T.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2023-05-10, release date: 2023-08-23, Last modification date: 2023-10-11)
Primary citation	Yang, M.H.,Tran, T.H.,Hunt, B.,Agnor, R.,Johnson, C.W.,Shui, B.,Waybright, T.J.,Nowak, J.A.,Stephen, A.G.,Simanshu, D.K.,Haigis, K.M. Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity. Cancer Res., 83:3176-3183, 2023 Cited by PubMed: 37556505 DOI: 10.1158/0008-5472.CAN-22-3210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation