4NCY
 
 | | In situ trypsin crystallized on a MiTeGen micromesh with imidazole ligand | | Descriptor: | 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... | | Authors: | Yin, X, Scalia, A, Leroy, L, Cuttitta, C.M, Polizzo, G.M, Ericson, D.L, Roessler, C.G, Campos, O, Agarwal, R, Allaire, M, Orville, A.M, Jackimowicz, R, Ma, M.Y, Sweet, R.M, Soares, A.S. | | Deposit date: | 2013-10-25 | | Release date: | 2014-04-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes.
Acta Crystallogr.,Sect.D, 70, 2014
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1I24
 | | HIGH RESOLUTION CRYSTAL STRUCTURE OF THE WILD-TYPE PROTEIN SQD1, WITH NAD AND UDP-GLUCOSE | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, SULFOLIPID BIOSYNTHESIS PROTEIN SQD1, ... | | Authors: | Theisen, M.J, Sanda, S.L, Ginell, S.L, Benning, C, Garavito, R.M. | | Deposit date: | 2001-02-05 | | Release date: | 2003-07-01 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Characterization of the Active Site of Udp-Sulfoquinovose Synthase: Formation of the Sulfonic Acid Product in the Crystalline State
To be Published
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4OX3
 | | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | | Descriptor: | PHOSPHATE ION, Putative carboxypeptidase YodJ, ZINC ION | | Authors: | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | | Deposit date: | 2014-02-04 | | Release date: | 2014-06-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition.
Structure, 22, 2014
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1HRJ
 | | HUMAN RANTES, NMR, 13 STRUCTURES | | Descriptor: | HUMAN REGULATED UPON ACTIVATION NORMAL T-CELL EXPRESSED AND SECRETED | | Authors: | Chung, C, Cooke, R.M, Proudfoot, A.E.I, Wells, T.N.C. | | Deposit date: | 1995-08-18 | | Release date: | 1996-10-14 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | The three-dimensional solution structure of RANTES.
Biochemistry, 34, 1995
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1HKN
 | | A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate | | Descriptor: | 5-AMINO-NAPHTALENE-2-MONOSULFONATE, HEPARIN-BINDING GROWTH FACTOR 1 | | Authors: | Fernandez-Tornero, C, Lozano, R.M, Gimenez-Gallego, G, Romero, A. | | Deposit date: | 2003-03-10 | | Release date: | 2004-03-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Leads for Development of New Naphthalenesulfonate Derivatives with Enhanced Antiangiogenic Activity: Crystal Structure of Acidic Fibroblast Growth Factor in Complex with 5-Amino-2-Naphthalenesulfonate
J.Biol.Chem., 278, 2003
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1PNV
 | | Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and Vancomycin | | Descriptor: | GLYCOSYLTRANSFERASE GTFA, THYMIDINE-5'-DIPHOSPHATE, VANCOMYCIN, ... | | Authors: | Mulichak, A.M, Losey, H.C, Lu, W, Wawrzak, Z, Walsh, C.T, Garavito, R.M. | | Deposit date: | 2003-06-13 | | Release date: | 2003-08-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
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4JG7
 | | Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide | | Descriptor: | (2R)-2-cyano-3-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylcarbonyl)phenyl]propanamide, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | Authors: | Miller, R.M, Paavilainen, V.O, Krishnan, S, Serafimova, I.M, Taunton, J. | | Deposit date: | 2013-02-28 | | Release date: | 2013-04-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.0002 Å) | | Cite: | Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
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1F4D
 | | CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL | | Descriptor: | GLYCEROL, N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL, SULFATE ION, ... | | Authors: | Erlanson, D.A, Braisted, A.C, Raphael, D.R, Randal, M, Stroud, R.M, Gordon, E, Wells, J.A. | | Deposit date: | 2000-06-07 | | Release date: | 2000-06-22 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Site-directed ligand discovery.
Proc.Natl.Acad.Sci.USA, 97, 2000
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4GDO
 | | Structure of a fragment of the rod domain of plectin | | Descriptor: | Plectin | | Authors: | De Pereda, J.M, Buey, R.M, Uson, I, Sammito, M.D, De Marino, I. | | Deposit date: | 2012-08-01 | | Release date: | 2013-09-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Exploiting tertiary structure through local folds for crystallographic phasing.
Nat.Methods, 10, 2013
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1RC2
 | | 2.5 Angstrom Resolution X-ray Structure of Aquaporin Z | | Descriptor: | 2-O-octyl-beta-D-glucopyranose, Aquaporin Z | | Authors: | Savage, D.F, Egea, P.F, Robles, Y.C, O'Connell III, J.D, Stroud, R.M. | | Deposit date: | 2003-11-03 | | Release date: | 2003-11-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z
Plos Biol., 1, 2003
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4FVQ
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1NG1
 | | N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CADMIUM ION, ... | | Authors: | Freymann, D.M, Stroud, R.M, Walter, P. | | Deposit date: | 1998-04-30 | | Release date: | 1999-07-30 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nat.Struct.Biol., 6, 1999
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2Q9Z
 | | Trichodiene synthase: Complex with inorganic pyrophosphate resulting from the reaction with 2-fluorofarnesyl diphosphate | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Vedula, L.S, Zhao, Y, Coates, R.M, Koyama, T, Cane, D.E, Christianson, D.W. | | Deposit date: | 2007-06-14 | | Release date: | 2007-10-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Exploring biosynthetic diversity with trichodiene synthase.
Arch.Biochem.Biophys., 466, 2007
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4JRA
 | | CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C | | Descriptor: | Botulinum neurotoxin type A, CHLORIDE ION, SODIUM ION, ... | | Authors: | Benoit, R.M, Frey, D, Wieser, M.M, Jaussi, R, Schertler, G.F.X, Capitani, G, Kammerer, R.A. | | Deposit date: | 2013-03-21 | | Release date: | 2013-11-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
Nature, 505, 2014
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4JG8
 | | Structure of RSK2 T493M CTD mutant bound to 2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide | | Descriptor: | (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide, Ribosomal protein S6 kinase alpha-3 | | Authors: | Miller, R.M, Paavilainen, V.O, Krishnan, S, Serafimova, I.M, Taunton, J. | | Deposit date: | 2013-02-28 | | Release date: | 2013-04-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.1002 Å) | | Cite: | Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
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4HNX
 | | The NatA Acetyltransferase Complex Bound To ppGpp | | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1 | | Authors: | Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D. | | Deposit date: | 2012-10-21 | | Release date: | 2014-03-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.339 Å) | | Cite: | The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
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2K9B
 | | Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy | | Descriptor: | Dermadistinctin-K | | Authors: | Moraes, C.M, Verly, R.M, Resende, J.M, Aisenbrey, C, Bemquerer, M.P, Pilo-Veloso, D, Valente, A, Almeida, F.C.L, Bechinger, B. | | Deposit date: | 2008-10-07 | | Release date: | 2009-04-14 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy.
Biophys.J., 96, 2009
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2KIH
 | | S31N mutant of M2 proton channel | | Descriptor: | Matrix protein 2 | | Authors: | Pielak, R.M. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-19 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Mechanism of drug inhibition and drug resistance of influenza A M2 channel.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1RPN
 | | Crystal Structure of GDP-D-mannose 4,6-dehydratase in complexes with GDP and NADPH | | Descriptor: | GDP-mannose 4,6-dehydratase, GUANOSINE-5'-DIPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Webb, N.A, Mulichak, A.M, Lam, J.S, Rocchetta, H.L, Garavito, R.M. | | Deposit date: | 2003-12-03 | | Release date: | 2004-02-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway.
Protein Sci., 13, 2004
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2R5P
 | | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir | | Descriptor: | CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, Protease, ... | | Authors: | Coman, R.M, Robbins, A.H, McKenna, R, Dunn, B.M. | | Deposit date: | 2007-09-04 | | Release date: | 2007-11-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Contribution of Naturally Occurring Polymorphisms in Altering the Biochemical and Structural Characteristics of HIV-1 Subtype C Protease
Biochemistry, 47, 2008
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1RJ9
 | | Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY) | | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Signal Recognition Protein, ... | | Authors: | Egea, P.F, Shan, S.O, Napetschnig, J, Savage, D.F, Walter, P, Stroud, R.M. | | Deposit date: | 2003-11-18 | | Release date: | 2004-01-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Substrate twinning activates the signal recognition particle and its receptor
Nature, 427, 2004
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4JNG
 | | Schmallenberg virus nucleoprotein-RNA complex | | Descriptor: | Nucleocapsid protein, RNA (42-MER) | | Authors: | Dong, H.H, Li, P, Bottcher, B, Elliott, R.M, Dong, C.J. | | Deposit date: | 2013-03-15 | | Release date: | 2013-07-31 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism.
Rna, 19, 2013
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4JUL
 | | Crystal structure of H5N1 influenza virus hemagglutinin, clade 2.3.4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | | Authors: | DuBois, R.M, Zaraket, H, Reddivari, M, Coop, T, Heath, R.J, White, S.W, Russell, C.J. | | Deposit date: | 2013-03-25 | | Release date: | 2014-05-07 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.7927 Å) | | Cite: | To be published
To be Published
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4J6E
 | | Structure of LPXI D225A Mutant | | Descriptor: | (2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate, UDP-2,3-diacylglucosamine pyrophosphatase LpxI | | Authors: | Metzger IV, L.E, Lee, J.K, Finer-Moore, J.S, Raetz, C.R.H, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) | | Deposit date: | 2013-02-11 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | LpxI structures reveal how a lipid A precursor is synthesized.
Nat.Struct.Mol.Biol., 19, 2012
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4JUK
 | | Crystal structure of H5N1 influenza virus hemagglutinin, clade 2.3.2.1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ... | | Authors: | DuBois, R.M, Zaraket, H, Reddivari, M, Coop, T, Heath, R.J, White, S.W, Russell, C.J. | | Deposit date: | 2013-03-25 | | Release date: | 2014-05-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.7502 Å) | | Cite: | To be published
To be Published
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