4JG8

Structure of RSK2 T493M CTD mutant bound to 2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide

Summary for 4JG8

Entry DOI	10.2210/pdb4jg8/pdb
Descriptor	Ribosomal protein S6 kinase alpha-3, (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide (3 entities in total)
Functional Keywords	protein kinase, phosphorylation, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P51812
Total number of polymer chains	1
Total formula weight	40550.15
Authors	Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. (deposition date: 2013-02-28, release date: 2013-04-10, Last modification date: 2023-12-27)
Primary citation	Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc., 135:5298-5301, 2013 Cited by PubMed: 23540679 DOI: 10.1021/ja401221b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1002 Å)

Structure validation