4FVQ

Crystal structure of the Jak2 pseudokinase domain (Mg-ATP-bound form)

Summary for 4FVQ

Entry DOI	10.2210/pdb4fvq/pdb
Related	4FVP 4FVR
Descriptor	Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	janus protein kinase, pseudokinase, atp binding, phosphorylation, transferase
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains	1
Total formula weight	33770.54
Authors	Bandaranayake, R.M.,Hubbard, S.R. (deposition date: 2012-06-29, release date: 2012-07-25, Last modification date: 2023-09-13)
Primary citation	Bandaranayake, R.M.,Ungureanu, D.,Shan, Y.,Shaw, D.E.,Silvennoinen, O.,Hubbard, S.R. Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Nat.Struct.Mol.Biol., 19:754-759, 2012 Cited by PubMed: 22820988 DOI: 10.1038/nsmb.2348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation