Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4FVQ

Crystal structure of the Jak2 pseudokinase domain (Mg-ATP-bound form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE ATP A 901
ChainResidue
ALEU551
APHE628
AVAL629
ASER633
AASN673
ALYS677
AASN678
ALEU680
AMG902
AHOH1027
AHOH1034
AGLY554
AHOH1037
AHOH1061
AHOH1075
AHOH1084
AHOH1088
AHOH1093
AHOH1144
AHOH1145
AHOH1146
AHOH1147
ATHR555
ATHR557
AILE559
ALEU579
ALYS581
AGLN626
AGLU627

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 902
ChainResidue
AASN678
AATP901
AHOH1144
AHOH1146
AHOH1147

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT A 903
ChainResidue
AASN673
AARG715
ATRP718
AHOH1112

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 904
ChainResidue
APHE560
AGLU621
AHOH1055

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon