4JG7
Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide
Summary for 4JG7
Entry DOI | 10.2210/pdb4jg7/pdb |
Descriptor | Ribosomal protein S6 kinase alpha-3, (2R)-2-cyano-3-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylcarbonyl)phenyl]propanamide, SODIUM ION, ... (4 entities in total) |
Functional Keywords | protein kinase, phosphorylation, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P51812 |
Total number of polymer chains | 1 |
Total formula weight | 40408.87 |
Authors | Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. (deposition date: 2013-02-28, release date: 2013-04-10, Last modification date: 2023-09-20) |
Primary citation | Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc., 135:5298-5301, 2013 Cited by PubMed: 23540679DOI: 10.1021/ja401221b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.0002 Å) |
Structure validation
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