4JG7

Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ribosomal protein S6 kinase alpha-3	polymer	355	40067.6	1	UniProt (P51812) Pfam (PF00069) In PDB	Homo sapiens (human)	S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2
2	A	(2R)-2-cyano-3-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylcarbonyl)phenyl]propanamide	non-polymer		318.3	1	Chemie (1LC)
3	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4		water	water		18.0	22	Chemie (HOH)

Sequence modifications

A: 399 - 740 (UniProt: P51812)

PDB	External Database	Details
Ala 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
Val 393	-	expression tag
Asp 394	-	expression tag
Asp 395	-	expression tag
Asp 396	-	expression tag
Asp 397	-	expression tag
Lys 398	-	expression tag
Glu 591	Lys 591	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40067.6
Non-Polymers*	Number of molecules	2
	Total formula weight	341.3
All*	Total formula weight	40408.9

*Water molecules are not included.