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PDB: 120 件
2OVR
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BU of 2ovr by Molmil
Structure of the Skp1-Fbw7-CyclinEdegN complex
分子名称: F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ...
著者Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P.
登録日2007-02-14
公開日2007-04-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
Mol.Cell, 26, 2007
2QSH
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BU of 2qsh by Molmil
Crystal structure of Rad4-Rad23 bound to a mismatch DNA
分子名称: DNA repair protein RAD4, UV excision repair protein RAD23, bottom strand of the mismatch DNA, ...
著者Min, J.-H, Pavletich, N.P.
登録日2007-07-31
公開日2007-10-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.805 Å)
主引用文献Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Nature, 449, 2007
2QSG
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BU of 2qsg by Molmil
Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA
分子名称: DNA repair protein RAD4, UV excision repair protein RAD23, damaged strand of the CPD-mismatch DNA, ...
著者Min, J.-H, Pavletich, N.P.
登録日2007-07-31
公開日2007-10-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Nature, 449, 2007
1P22
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BU of 1p22 by Molmil
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
分子名称: Beta-catenin, F-box/WD-repeat protein 1A, Skp1
著者Wu, G, Xu, G, Schulman, B.A, Jeffrey, P.D, Harper, J.W, Pavletich, N.P.
登録日2003-04-14
公開日2003-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
Mol.Cell, 11, 2003
2QSF
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BU of 2qsf by Molmil
Crystal structure of the Rad4-Rad23 complex
分子名称: DNA repair protein RAD4, UV excision repair protein RAD23
著者Min, J.-H, Pavletich, N.P.
登録日2007-07-31
公開日2007-10-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Nature, 449, 2007
1T4W
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BU of 1t4w by Molmil
Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
分子名称: C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION
著者Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D.
登録日2004-04-30
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1.
Structure, 12, 2004
1A41
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BU of 1a41 by Molmil
TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS
分子名称: SULFATE ION, TOPOISOMERASE I
著者Cheng, C, Kussie, P, Pavletich, N, Shuman, S.
登録日1998-02-10
公開日1999-06-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.
Cell(Cambridge,Mass.), 92, 1998
1BI8
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BU of 1bi8 by Molmil
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX
分子名称: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR
著者Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P.
登録日1998-06-22
公開日1999-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
1BI7
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MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
分子名称: CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR
著者Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P.
登録日1998-06-22
公開日1999-01-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
1C3P
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BU of 1c3p by Molmil
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS
分子名称: PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN))
著者Finnin, M.S, Donigian, J.R, Pavletich, N.P.
登録日1999-07-28
公開日1999-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1BYQ
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BU of 1byq by Molmil
HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (HEAT SHOCK PROTEIN 90)
著者Russo, A.A, Pavletich, N.P.
登録日1998-10-19
公開日1998-10-28
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
J.Cell Biol., 143, 1998
1C3S
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BU of 1c3s by Molmil
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA
分子名称: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION
著者Finnin, M.S, Donigian, J.R, Pavletich, N.P.
登録日1999-07-28
公開日1999-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C3R
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BU of 1c3r by Molmil
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A
分子名称: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), TRICHOSTATIN A, ZINC ION
著者Finnin, M.S, Donigian, J.R, Pavletich, N.P.
登録日1999-07-28
公開日1999-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature, 401, 1999
1C4Z
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BU of 1c4z by Molmil
STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY
分子名称: UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A
著者Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P.
登録日1999-10-14
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science, 286, 1999
1C26
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BU of 1c26 by Molmil
CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN
分子名称: P53 TUMOR SUPPRESSOR
著者Jeffrey, P.D, Gorina, S, Pavletich, N.P.
登録日1999-07-22
公開日1999-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.
Science, 267, 1995
1TUP
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BU of 1tup by Molmil
TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA
分子名称: DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR ), ...
著者Cho, Y, Gorina, S, Jeffrey, P.D, Pavletich, N.P.
登録日1995-07-11
公開日1995-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
Science, 265, 1994
3EI4
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BU of 3ei4 by Molmil
Structure of the hsDDB1-hsDDB2 complex
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2
著者Scrima, A, Pavletich, N.P, Thoma, N.H.
登録日2008-09-15
公開日2009-01-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell(Cambridge,Mass.), 135, 2008
3CMT
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BU of 3cmt by Molmil
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*DTP*DTP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DCP*DTP*DTP*DTP*DT)-3'), DNA (5'-D(P*DGP*DGP*DTP*DGP*DGP*DG)-3'), ...
著者Chen, Z, Yang, H, Pavletich, N.P.
登録日2008-03-24
公開日2008-05-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Nature, 453, 2008
2AST
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BU of 2ast by Molmil
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
分子名称: BENZAMIDINE, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ...
著者Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P.
登録日2005-08-24
公開日2005-10-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
2AZE
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BU of 2aze by Molmil
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
分子名称: Retinoblastoma-associated protein, Transcription factor Dp-1, Transcription factor E2F1
著者Rubin, S.M, Gall, A.L, Zheng, N, Pavletich, N.P.
登録日2005-09-10
公開日2006-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
Cell(Cambridge,Mass.), 123, 2005
2ASS
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BU of 2ass by Molmil
Crystal structure of the Skp1-Skp2-Cks1 complex
分子名称: BENZAMIDINE, Cyclin-dependent kinases regulatory subunit 1, PHOSPHATE ION, ...
著者Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P.
登録日2005-08-24
公開日2005-10-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
1VCB
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BU of 1vcb by Molmil
THE VHL-ELONGINC-ELONGINB STRUCTURE
分子名称: PROTEIN (ELONGIN B), PROTEIN (ELONGIN C), PROTEIN (VHL)
著者Stebbins, C.E, Kaelin, W.G, Pavletich, N.P.
登録日1999-03-13
公開日1999-04-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Science, 284, 1999
1MQB
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BU of 1mqb by Molmil
Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase
分子名称: Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C, Pavletich, N, Rogers, J, Sang, B.C, Scheibe, D.N, Swanson, R.V, Thompson, D.A.
登録日2002-09-16
公開日2003-09-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
Structure, 10, 2003
1YES
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BU of 1yes by Molmil
HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION
分子名称: HEAT SHOCK PROTEIN 90
著者Stebbins, C.E, Russo, A.A, Pavletich, N.P.
登録日1997-03-25
公開日1998-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell(Cambridge,Mass.), 89, 1997
1YET
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GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN
分子名称: GELDANAMYCIN, HEAT SHOCK PROTEIN 90
著者Stebbins, C.E, Russo, A.A, Pavletich, N.P.
登録日1997-03-25
公開日1998-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell(Cambridge,Mass.), 89, 1997

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