1C3S

CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA

Summary for 1C3S

Entry DOI	10.2210/pdb1c3s/pdb
Related	1C3R 1C3S
Descriptor	HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), ZINC ION, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... (4 entities in total)
Functional Keywords	alpha/beta fold, hydroxamic acid, penta-coordinated zinc, charge-relay system, lyase
Biological source	Aquifex aeolicus
Total number of polymer chains	1
Total formula weight	43031.37
Authors	Finnin, M.S.,Donigian, J.R.,Pavletich, N.P. (deposition date: 1999-07-28, release date: 1999-09-15, Last modification date: 2024-02-07)
Primary citation	Finnin, M.S.,Donigian, J.R.,Cohen, A.,Richon, V.M.,Rifkind, R.A.,Marks, P.A.,Breslow, R.,Pavletich, N.P. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401:188-193, 1999 Cited by PubMed: 10490031 DOI: 10.1038/43710 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation