1P22

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase

Summary for 1P22

• Entry DOI: 10.2210/pdb1p22/pdb
• Descriptor: F-box/WD-repeat protein 1A, Skp1, Beta-catenin (3 entities in total)
• Functional Keywords: ubiquitination, degradation, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q9Y297 P35222
• Total number of polymer chains: 3
• Total formula weight: 69195.61

Authors

Wu, G.,Xu, G.,Schulman, B.A.,Jeffrey, P.D.,Harper, J.W.,Pavletich, N.P. (deposition date: 2003-04-14, release date: 2003-07-08, Last modification date: 2011-07-13)

• Primary citation: Wu, G.,Xu, G.,Schulman, B.A.,Jeffrey, P.D.,Harper, J.W.,Pavletich, N.P.; Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase; Mol.Cell, 11:1445-1456, 2003; PubMed: 12820959; DOI: 10.1016/S1097-2765(03)00234-X

Experimental method

X-RAY DIFFRACTION (2.95 Å)