1P22
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | F-box/WD-repeat protein 1A | polymer | 435 | 49699.8 | 1 | UniProt (Q9Y297) Pfam (PF12937) Pfam (PF00400) | Homo sapiens (human) | F-box and WD-repeats protein beta-TrCP, E3RSIkappaB, pIkappaBalpha-E3 receptor subunit |
| 2 | B (B) | Skp1 | polymer | 145 | 16590.9 | 1 | UniProt (P63208) Pfam (PF01466) Pfam (PF03931) | Homo sapiens (human) | |
| 3 | C (C) | Beta-catenin | polymer | 26 | 2904.9 | 1 | UniProt (P35222) | Homo sapiens (human) | PRO2286 |
Sequence modifications
A: 139 - 569 (UniProt: Q9Y297)
C: 19 - 44 (UniProt: P35222)
| PDB | External Database | Details |
|---|---|---|
| Ser 135 | - | cloning artifact |
| Pro 136 | - | cloning artifact |
| Ala 137 | - | cloning artifact |
| Ile 138 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Sep 33 | Ser 33 | modified residue |
| Sep 37 | Ser 37 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69195.6 | |
| All* | Total formula weight | 69195.6 |
