1BI8
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX
Summary for 1BI8
| Entry DOI | 10.2210/pdb1bi8/pdb |
| Descriptor | CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR (2 entities in total) |
| Functional Keywords | cyclin dependent kinase, cyclin dependent kinase inhibitory protein, cdk, ink4, cell cycle, complex (kinase-inhibitor), complex (kinase-inhibitor) complex, complex (kinase/inhibitor) |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 109420.99 |
| Authors | Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. (deposition date: 1998-06-22, release date: 1999-01-13, Last modification date: 2024-04-03) |
| Primary citation | Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395:237-243, 1998 Cited by PubMed: 9751050DOI: 10.1038/26155 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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