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1BI8

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0001726cellular_componentruffle
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002244biological_processhematopoietic progenitor cell differentiation
A0003323biological_processtype B pancreatic cell development
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0007219biological_processNotch signaling pathway
A0008285biological_processnegative regulation of cell population proliferation
A0009615biological_processresponse to virus
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0010628biological_processpositive regulation of gene expression
A0014002biological_processastrocyte development
A0016301molecular_functionkinase activity
A0021542biological_processdentate gyrus development
A0021670biological_processlateral ventricle development
A0030097biological_processhemopoiesis
A0030154biological_processcell differentiation
A0030332molecular_functioncyclin binding
A0033077biological_processT cell differentiation in thymus
A0042063biological_processgliogenesis
A0042127biological_processregulation of cell population proliferation
A0042995cellular_componentcell projection
A0043697biological_processcell dedifferentiation
A0045596biological_processnegative regulation of cell differentiation
A0045638biological_processnegative regulation of myeloid cell differentiation
A0045646biological_processregulation of erythrocyte differentiation
A0045656biological_processnegative regulation of monocyte differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045786biological_processnegative regulation of cell cycle
A0048146biological_processpositive regulation of fibroblast proliferation
A0048699biological_processgeneration of neurons
A0050680biological_processnegative regulation of epithelial cell proliferation
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060218biological_processhematopoietic stem cell differentiation
A0097131cellular_componentcyclin D1-CDK6 complex
A0097132cellular_componentcyclin D2-CDK6 complex
A0097133cellular_componentcyclin D3-CDK6 complex
A0098770molecular_functionFBXO family protein binding
A0106310molecular_functionprotein serine kinase activity
A1902036biological_processregulation of hematopoietic stem cell differentiation
A2000145biological_processregulation of cell motility
A2000773biological_processnegative regulation of cellular senescence
B0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
B0000731biological_processDNA synthesis involved in DNA repair
B0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007605biological_processsensory perception of sound
B0008285biological_processnegative regulation of cell population proliferation
B0009411biological_processresponse to UV
B0019901molecular_functionprotein kinase binding
B0030308biological_processnegative regulation of cell growth
B0032526biological_processresponse to retinoic acid
B0033280biological_processresponse to vitamin D
B0042326biological_processnegative regulation of phosphorylation
B0048102biological_processautophagic cell death
B0097129cellular_componentcyclin D2-CDK4 complex
B1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B1902807biological_processnegative regulation of cell cycle G1/S phase transition
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0001726cellular_componentruffle
C0001954biological_processpositive regulation of cell-matrix adhesion
C0002244biological_processhematopoietic progenitor cell differentiation
C0003323biological_processtype B pancreatic cell development
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0007219biological_processNotch signaling pathway
C0008285biological_processnegative regulation of cell population proliferation
C0009615biological_processresponse to virus
C0010389biological_processregulation of G2/M transition of mitotic cell cycle
C0010468biological_processregulation of gene expression
C0010628biological_processpositive regulation of gene expression
C0014002biological_processastrocyte development
C0016301molecular_functionkinase activity
C0021542biological_processdentate gyrus development
C0021670biological_processlateral ventricle development
C0030097biological_processhemopoiesis
C0030154biological_processcell differentiation
C0030332molecular_functioncyclin binding
C0033077biological_processT cell differentiation in thymus
C0042063biological_processgliogenesis
C0042127biological_processregulation of cell population proliferation
C0042995cellular_componentcell projection
C0043697biological_processcell dedifferentiation
C0045596biological_processnegative regulation of cell differentiation
C0045638biological_processnegative regulation of myeloid cell differentiation
C0045646biological_processregulation of erythrocyte differentiation
C0045656biological_processnegative regulation of monocyte differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045786biological_processnegative regulation of cell cycle
C0048146biological_processpositive regulation of fibroblast proliferation
C0048699biological_processgeneration of neurons
C0050680biological_processnegative regulation of epithelial cell proliferation
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0060218biological_processhematopoietic stem cell differentiation
C0097131cellular_componentcyclin D1-CDK6 complex
C0097132cellular_componentcyclin D2-CDK6 complex
C0097133cellular_componentcyclin D3-CDK6 complex
C0098770molecular_functionFBXO family protein binding
C0106310molecular_functionprotein serine kinase activity
C1902036biological_processregulation of hematopoietic stem cell differentiation
C2000145biological_processregulation of cell motility
C2000773biological_processnegative regulation of cellular senescence
D0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
D0000731biological_processDNA synthesis involved in DNA repair
D0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007605biological_processsensory perception of sound
D0008285biological_processnegative regulation of cell population proliferation
D0009411biological_processresponse to UV
D0019901molecular_functionprotein kinase binding
D0030308biological_processnegative regulation of cell growth
D0032526biological_processresponse to retinoic acid
D0033280biological_processresponse to vitamin D
D0042326biological_processnegative regulation of phosphorylation
D0048102biological_processautophagic cell death
D0097129cellular_componentcyclin D2-CDK4 complex
D1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
D1902807biological_processnegative regulation of cell cycle G1/S phase transition
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGKVFkArdlknggrf.........VALK
ChainResidueDetails
AILE19-LYS43

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpqNILV
ChainResidueDetails
AVAL141-VAL153

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:12665801
ChainResidueDetails
BMET1
DMET1

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE19
ALYS43
CILE19
CLYS43

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1
CMET1

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR13
CTYR13

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR24
CTYR24

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR49
ATHR70
ATHR325
CTHR49
CTHR70
CTHR325

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:11828325
ChainResidueDetails
ATHR177
CTHR177

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS264
CLYS264

227111

PDB entries from 2024-11-06

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