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PDB: 73 results

7YP8
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Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Leucyl-sulfamoyl 3-deazaadenosine
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2022-08-02
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The essential role of a structured water in base recognition of Class II aminoacyl-tRNA synthetases
To be published
6RLV
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BU of 6rlv by Molmil
Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine
Descriptor: 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, GLYCEROL, MALONATE ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6RLU
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Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine
Descriptor: 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, GLYCEROL, MALONATE ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6RLT
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BU of 6rlt by Molmil
Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine
Descriptor: 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, GLYCEROL, MALONATE ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6Q8A
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BU of 6q8a by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine
Descriptor: 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q89
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Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with the Intermediate Analog 5'-O-(N-(L-Leucyl)-Sulfamoyl)Adenosine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q8C
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BU of 6q8c by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, Leucine--tRNA ligase, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q8B
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BU of 6q8b by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)N3-methyluridine
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6S30
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BU of 6s30 by Molmil
Crystal Structure of Seryl-tRNA Synthetase from Klebsiella pneumoniae
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Serine--tRNA ligase
Authors:Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V.
Deposit date:2019-06-23
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
7AP2
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BU of 7ap2 by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound LeuS7HMDDA
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
7AP1
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BU of 7ap1 by Molmil
Klebsiella pneumoniae Seryl-tRNA synthetase in Complex with Compound SerS7HMDDA
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Serine-tRNA ligase, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-11-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
7A0P
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BU of 7a0p by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11i
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-08-10
Release date:2020-12-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
7OSZ
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BU of 7osz by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4d
Descriptor: 3-[(2-methylphenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT0
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BU of 7ot0 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h
Descriptor: 3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OSY
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BU of 7osy by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT1
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BU of 7ot1 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3c
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT3
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BU of 7ot3 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3b
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT2
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BU of 7ot2 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4j
Descriptor: 3-[[2-(trifluoromethyl)phenyl]methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7NU9
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BU of 7nu9 by Molmil
Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP and L-leucinol
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-03-11
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
7NU5
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BU of 7nu5 by Molmil
Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with L-leucine
Descriptor: LEUCINE, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-03-11
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
7NUC
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Crystal Structure of Neisseria gonorrhoeae LeuRS L550G mutant in Complex with ATP and L-leucinol
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-03-11
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
7NU3
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BU of 7nu3 by Molmil
Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with ATP and L-leucinol
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-03-11
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
7NU0
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BU of 7nu0 by Molmil
Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with ATP and L-leucinol
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-03-11
Release date:2022-09-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
6YKQ
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BU of 6ykq by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKN
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Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021

 

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