6Q8C

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine

Summary for 6Q8C

Entry DOI	10.2210/pdb6q8c/pdb
Related	6HB5 6HB6 6HB7 6I5Y
Descriptor	Leucine--tRNA ligase, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, ZINC ION, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, rossmann fold, trna synthetase, ligase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	98835.63
Authors	Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2018-12-14, release date: 2019-04-17, Last modification date: 2024-01-24)
Primary citation	Nautiyal, M.,De Graef, S.,Pang, L.,Gadakh, B.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173:154-166, 2019 Cited by PubMed: 30995568 DOI: 10.1016/j.ejmech.2019.04.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation