Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine

Summary for 6RLU

Related6HHY 6HHZ 6HI0 6HHV 6HHW 6HHX 6HDZ 6HE1 6HE3
DescriptorSeryl-tRNA synthetase, putative, GLYCEROL, SODIUM ION, ... (6 entities in total)
Functional Keywordscoil-coil, beta barrel, trna synthetase, inhibitor, complex, ligase
Biological sourceTrypanosoma brucei gambiense
Total number of polymer chains2
Total molecular weight109733.98
Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2019-05-02, release date: 2020-01-08, Last modification date: 2020-01-15)
Primary citation
Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Zorzini, V.,Economou, A.,Strelkov, S.V.,Van Aerschot, A.,Weeks, S.D.
Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 2020
PubMed: 31869198 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.9b00887
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18710 0.8% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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