7AP2

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound LeuS7HMDDA

Summary for 7AP2

Entry DOI	10.2210/pdb7ap2/pdb
Descriptor	Leucine--tRNA ligase, 1,2-ETHANEDIOL, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, rossmann fold, trna synthetase, ligase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	98886.72
Authors	Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-10-15, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citation	Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. Molecules, 25:-, 2020 Cited by PubMed: 33081246 DOI: 10.3390/molecules25204751 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation