7RA7
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![BU of 7ra7 by Molmil](/molmil-images/mine/7ra7) | Crystal structure of rabbit anti-HIV Fab 11A | Descriptor: | 11A Fab heavy chain, 11A Fab light chain, PENTAETHYLENE GLYCOL, ... | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2021-06-30 | Release date: | 2022-07-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions To Be Published
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5W3Q
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![BU of 5w3q by Molmil](/molmil-images/mine/5w3q) | L28F E.coli DHFR in complex with NADPH | Descriptor: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Oyen, D, Wright, P.E, Wilson, I.A. | Deposit date: | 2017-06-08 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
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6PBW
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![BU of 6pbw by Molmil](/molmil-images/mine/6pbw) | Crystal structure of Fab667 complex | Descriptor: | Fab667 heavy chain, Fab667 light chain, GLYCEROL, ... | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2019-06-14 | Release date: | 2020-03-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.058 Å) | Cite: | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. Plos Pathog., 16, 2020
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6PBV
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![BU of 6pbv by Molmil](/molmil-images/mine/6pbv) | Crystal structure of Fab668 complex | Descriptor: | 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ... | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2019-06-14 | Release date: | 2020-03-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.566 Å) | Cite: | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. Plos Pathog., 16, 2020
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5CC9
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![BU of 5cc9 by Molmil](/molmil-images/mine/5cc9) | |
5CCC
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![BU of 5ccc by Molmil](/molmil-images/mine/5ccc) | |
3K74
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![BU of 3k74 by Molmil](/molmil-images/mine/3k74) | Disruption of protein dynamics by an allosteric effector antibody | Descriptor: | Dihydrofolate reductase, Nanobody | Authors: | Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J. | Deposit date: | 2009-10-12 | Release date: | 2010-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J.Mol.Biol., 407, 2011
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6AXL
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![BU of 6axl by Molmil](/molmil-images/mine/6axl) | Crystal structure of Fab317 complex | Descriptor: | Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2 | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2017-09-07 | Release date: | 2017-11-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6AXK
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![BU of 6axk by Molmil](/molmil-images/mine/6axk) | Crystal structure of Fab311 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, Fab311 heavy chain, ... | Authors: | Oyen, D, Wilson, I.A. | Deposit date: | 2017-09-07 | Release date: | 2017-11-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6VSR
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![BU of 6vsr by Molmil](/molmil-images/mine/6vsr) | |
6BQB
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![BU of 6bqb by Molmil](/molmil-images/mine/6bqb) | MGG4 Fab in complex with peptide | Descriptor: | GLYCEROL, MGG4 Fab heavy chain, MGG4 Fab light chain, ... | Authors: | Oyen, D, Tan, J, Lanzavecchia, A, Wilson, I.A. | Deposit date: | 2017-11-27 | Release date: | 2018-03-07 | Last modified: | 2018-04-25 | Method: | X-RAY DIFFRACTION (1.769 Å) | Cite: | A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein. Nat. Med., 24, 2018
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4EJ1
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![BU of 4ej1 by Molmil](/molmil-images/mine/4ej1) | |
4FHB
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![BU of 4fhb by Molmil](/molmil-images/mine/4fhb) | Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Oyen, D. | Deposit date: | 2012-06-06 | Release date: | 2013-04-24 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim.Biophys.Acta, 1834, 2013
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4EIG
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![BU of 4eig by Molmil](/molmil-images/mine/4eig) | CA1698 camel antibody fragment in complex with DHFR | Descriptor: | CA1698 camel antibody fragment, Dihydrofolate reductase | Authors: | Oyen, D, Srinivasan, V. | Deposit date: | 2012-04-05 | Release date: | 2013-04-24 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim.Biophys.Acta, 1834, 2013
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4EIZ
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![BU of 4eiz by Molmil](/molmil-images/mine/4eiz) | Structure of Nb113 bound to apoDHFR | Descriptor: | Dihydrofolate reductase, Nb113 Camel antibody fragment | Authors: | Oyen, D, Srinivasan, V. | Deposit date: | 2012-04-06 | Release date: | 2013-04-24 | Last modified: | 2013-10-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim.Biophys.Acta, 1834, 2013
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4I1N
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![BU of 4i1n by Molmil](/molmil-images/mine/4i1n) | |
4I13
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![BU of 4i13 by Molmil](/molmil-images/mine/4i13) | |
7RXP
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![BU of 7rxp by Molmil](/molmil-images/mine/7rxp) | |
7RXI
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![BU of 7rxi by Molmil](/molmil-images/mine/7rxi) | |
7RXL
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![BU of 7rxl by Molmil](/molmil-images/mine/7rxl) | |
7RXJ
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![BU of 7rxj by Molmil](/molmil-images/mine/7rxj) | |
7S0X
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![BU of 7s0x by Molmil](/molmil-images/mine/7s0x) | |
6UC5
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![BU of 6uc5 by Molmil](/molmil-images/mine/6uc5) | Fab397 in complex with NPNA peptide | Descriptor: | Fab397 heavy chain, Fab397 light chain, NPNA peptide | Authors: | Pholcharee, T, Oyen, D, Wilson, I.A. | Deposit date: | 2019-09-13 | Release date: | 2020-01-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein. J.Mol.Biol., 432, 2020
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6WG1
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![BU of 6wg1 by Molmil](/molmil-images/mine/6wg1) | |
6W00
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![BU of 6w00 by Molmil](/molmil-images/mine/6w00) | Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein | Descriptor: | Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ... | Authors: | Pholcharee, T, Oyen, D, Wilson, I.A. | Deposit date: | 2020-02-28 | Release date: | 2020-07-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum. Nat Commun, 12, 2021
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