7RXP

Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum

Summary for 7RXP

• Entry DOI: 10.2210/pdb7rxp/pdb
• Descriptor: Fab1512 light chain, Fab1512 heavy chain, Circumsporozoite protein, ... (4 entities in total)
• Functional Keywords: malaria, antibody, sporozoite, circumsporozoite protein, alpha-tsr domain, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 56498.35

Authors

Pholcharee, T.,Oyen, D.,Wilson, I.A. (deposition date: 2021-08-23, release date: 2022-03-16, Last modification date: 2024-04-03)

• Primary citation: Beutler, N.,Pholcharee, T.,Oyen, D.,Flores-Garcia, Y.,MacGill, R.S.,Garcia, E.,Calla, J.,Parren, M.,Yang, L.,Volkmuth, W.,Locke, E.,Regules, J.A.,Dutta, S.,Emerling, D.,Early, A.M.,Neafsey, D.E.,Winzeler, E.,King, C.R.,Zavala, F.,Burton, D.R.,Wilson, I.A.,Rogers, T.F.; A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.; Plos Pathog., 18:e1010409-e1010409, 2022; PubMed: 35344575; DOI: 10.1371/journal.ppat.1010409

Experimental method

X-RAY DIFFRACTION (1.761 Å)