5CC9
 
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5CCC
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5W3Q
 | | L28F E.coli DHFR in complex with NADPH | | 分子名称: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Oyen, D, Wright, P.E, Wilson, I.A. | | 登録日 | 2017-06-08 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | | 主引用文献 | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
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6PBW
 | | Crystal structure of Fab667 complex | | 分子名称: | Fab667 heavy chain, Fab667 light chain, GLYCEROL, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2019-06-14 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.058 Å) | | 主引用文献 | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
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6PBV
 | | Crystal structure of Fab668 complex | | 分子名称: | 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2019-06-14 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.566 Å) | | 主引用文献 | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
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3K74
 | | Disruption of protein dynamics by an allosteric effector antibody | | 分子名称: | Dihydrofolate reductase, Nanobody | | 著者 | Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J. | | 登録日 | 2009-10-12 | | 公開日 | 2010-10-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
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6AXL
 | | Crystal structure of Fab317 complex | | 分子名称: | Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2 | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2017-09-07 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6AXK
 | | Crystal structure of Fab311 complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, Fab311 heavy chain, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2017-09-07 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7RA7
 | | Crystal structure of rabbit anti-HIV Fab 11A | | 分子名称: | 11A Fab heavy chain, 11A Fab light chain, PENTAETHYLENE GLYCOL, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2021-06-30 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions
To Be Published
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6BQB
 | | MGG4 Fab in complex with peptide | | 分子名称: | GLYCEROL, MGG4 Fab heavy chain, MGG4 Fab light chain, ... | | 著者 | Oyen, D, Tan, J, Lanzavecchia, A, Wilson, I.A. | | 登録日 | 2017-11-27 | | 公開日 | 2018-03-07 | | 最終更新日 | 2018-04-25 | | 実験手法 | X-RAY DIFFRACTION (1.769 Å) | | 主引用文献 | A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nat. Med., 24, 2018
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6VSR
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4EIG
 | | CA1698 camel antibody fragment in complex with DHFR | | 分子名称: | CA1698 camel antibody fragment, Dihydrofolate reductase | | 著者 | Oyen, D, Srinivasan, V. | | 登録日 | 2012-04-05 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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4EIZ
 | | Structure of Nb113 bound to apoDHFR | | 分子名称: | Dihydrofolate reductase, Nb113 Camel antibody fragment | | 著者 | Oyen, D, Srinivasan, V. | | 登録日 | 2012-04-06 | | 公開日 | 2013-04-24 | | 最終更新日 | 2013-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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4I1N
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4EJ1
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4FHB
 | | Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Oyen, D. | | 登録日 | 2012-06-06 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
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4I13
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6WFZ
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6WFY
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6WFW
 | | Crystal structure of Fab364 in complex with NPNA2 peptide from circumsporozoite protein | | 分子名称: | Fab364 heavy chain, Fab364 light chain, Immunoglobulin G-binding protein G, ... | | 著者 | Pholcharee, T, Oyen, D, Wilson, I.A. | | 登録日 | 2020-04-04 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.093 Å) | | 主引用文献 | Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
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6WG2
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6W05
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6W00
 | | Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein | | 分子名称: | Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ... | | 著者 | Pholcharee, T, Oyen, D, Wilson, I.A. | | 登録日 | 2020-02-28 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | | 主引用文献 | Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
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6WG1
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6WFX
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