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PDB: 54 results
6OFY
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BU of 6ofy by Molmil
Crystal Structure of Arachidonic Acid bound to V349I murine COX-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ARACHIDONIC ACID, ...
Authors:Malkowski, M.G.
Deposit date:2019-04-01
Release date:2020-02-05
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.
Biochemistry, 58, 2019
1YCP
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BU of 1ycp by Molmil
THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
Descriptor: ALPHA THROMBIN, EPSILON THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-05-01
Release date:1998-05-06
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
1IGZ
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BU of 1igz by Molmil
Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ...
Authors:Malkowski, M.G, Thuresson, E.D, Smith, W.L, Garavito, R.M.
Deposit date:2001-04-18
Release date:2001-12-12
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
1IGX
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BU of 1igx by Molmil
Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5,8,11,14,17-EICOSAPENTAENOIC ACID, ...
Authors:Malkowski, M.G, Thuresson, E.D, Smith, W.L, Garavito, R.M.
Deposit date:2001-04-18
Release date:2001-12-12
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
1TVX
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BU of 1tvx by Molmil
NEUTROPHIL ACTIVATING PEPTIDE-2 VARIANT FORM M6L WITH FIVE ADDITIONAL AMINO TERMINAL RESIDUES (DSDLY)
Descriptor: NEUTROPHIL ACTIVATING PEPTIDE 2 VARIANT
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1996-11-05
Release date:1997-01-11
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence.
J.Mol.Biol., 266, 1997
2IP1
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BU of 2ip1 by Molmil
Crystal Structure Analysis of S. cerevisiae Tryptophanyl tRNA Synthetase
Descriptor: TETRAETHYLENE GLYCOL, Tryptophanyl-tRNA synthetase
Authors:Malkowski, M.G, Center for High-Throughput Structural Biology (CHTSB)
Deposit date:2006-10-11
Release date:2007-06-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1MKW
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BU of 1mkw by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor: ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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BU of 1mkx by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor: ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1DIY
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BU of 1diy by Molmil
CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARACHIDONIC ACID, ...
Authors:Malkowski, M.G, Ginell, S.L, Smith, W.L, Garavito, R.M.
Deposit date:1999-11-30
Release date:2000-09-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The productive conformation of arachidonic acid bound to prostaglandin synthase.
Science, 289, 2000
1NAP
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BU of 1nap by Molmil
THE CRYSTAL STRUCTURE OF RECOMBINANT HUMAN NEUTROPHIL-ACTIVATING PEPTIDE-2 (M6L) AT 1.9-ANGSTROMS RESOLUTION
Descriptor: NEUTROPHIL ACTIVATING PEPTIDE-2
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1994-12-19
Release date:1995-12-19
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.
J.Biol.Chem., 270, 1995
5JVZ
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BU of 5jvz by Molmil
Crystal structure of flurbiprofen bound to S121P murine COX-2 mutant
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malkowski, M.G, Orlando, B.J.
Deposit date:2016-05-11
Release date:2016-10-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.
J.Biol.Chem., 291, 2016
5JW1
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BU of 5jw1 by Molmil
Crystal structure of Celecoxib bound to S121P murine COX-2 mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, ...
Authors:Malkowski, M.G, Orlando, B.J.
Deposit date:2016-05-11
Release date:2016-10-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.822 Å)
Cite:Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.
J.Biol.Chem., 291, 2016
3TZI
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BU of 3tzi by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-09-27
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287, 2012
3K8J
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BU of 3k8j by Molmil
Structure of crystal form III of TP0453
Descriptor: 30kLP
Authors:Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3K8H
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BU of 3k8h by Molmil
Structure of crystal form I of TP0453
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 30kLP
Authors:Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3KRK
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BU of 3krk by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ...
Authors:Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
Deposit date:2009-11-18
Release date:2010-05-12
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
8T27
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BU of 8t27 by Molmil
Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible)
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid, ...
Authors:Clark, N.D, Malkowski, M.G.
Deposit date:2023-06-05
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
Plos Pathog., 19, 2023
8T1Z
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BU of 8t1z by Molmil
Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) Bound to Neu5Ac (NANA)
Descriptor: DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid, Sialidase, ...
Authors:Clark, N.D, Malkowski, M.G.
Deposit date:2023-06-05
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
Plos Pathog., 19, 2023
8T1Y
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BU of 8t1y by Molmil
Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) Bound to Neu5Ac2en (DANA)
Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, DI(HYDROXYETHYL)ETHER, Sialidase, ...
Authors:Clark, N.D, Malkowski, M.G.
Deposit date:2023-06-05
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
Plos Pathog., 19, 2023
8T26
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BU of 8t26 by Molmil
Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 3'-Sialyllactose (only Neu5Ac visible)
Descriptor: DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid, Sialidase, ...
Authors:Clark, N.D, Malkowski, M.G.
Deposit date:2023-06-05
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
Plos Pathog., 19, 2023
8T24
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BU of 8t24 by Molmil
Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352)- Fructose bound in CBM
Descriptor: CITRATE ANION, D-fructose, DI(HYDROXYETHYL)ETHER, ...
Authors:Clark, N.D, Malkowski, M.G.
Deposit date:2023-06-05
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
Plos Pathog., 19, 2023
4PH9
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BU of 4ph9 by Molmil
The structure of Ibuprofen bound to cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Orlando, B.J, Lucido, M.J, Malkowski, M.G.
Deposit date:2014-05-05
Release date:2014-11-26
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The structure of ibuprofen bound to cyclooxygenase-2.
J.Struct.Biol., 189, 2015
3QH0
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BU of 3qh0 by Molmil
X-ray crystal structure of palmitic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-01-25
Release date:2011-04-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.
J.Biol.Chem., 286, 2011
3QMO
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BU of 3qmo by Molmil
X-ray crystal structure of NS-398 bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-02-04
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of NS-398 bound to cyclooxygenase-2.
J.Struct.Biol., 176, 2011
4HHR
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BU of 4hhr by Molmil
Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)
Descriptor: Alpha-dioxygenase, CALCIUM ION, CHLORIDE ION, ...
Authors:Goulah, C.C, Zhu, G, Koszelak-Rosenblum, M, Malkowski, M.G.
Deposit date:2012-10-10
Release date:2013-02-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:The crystal structure of alpha-Dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily.
Biochemistry, 52, 2013

 

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