1FE2

CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.

Summary for 1FE2

Entry DOI	10.2210/pdb1fe2/pdb
Related	1DDX 1DIY 1PRH
Descriptor	PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	membrane protein, fatty acid, dihomo-gamma-linoleic acid, oxidoreductase, peroxidase, dioxygenase
Biological source	Ovis aries (sheep)
Total number of polymer chains	1
Total formula weight	69727.60
Authors	Thuresson, E.D.,Malkowski, M.G.,Lakkides, K.M.,Smith, W.L.,Garavito, R.M. (deposition date: 2000-07-20, release date: 2001-05-02, Last modification date: 2020-07-29)
Primary citation	Thuresson, E.D.,Malkowski, M.G.,Lakkides, K.M.,Rieke, C.J.,Mulichak, A.M.,Ginell, S.L.,Garavito, R.M.,Smith, W.L. Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases. J.Biol.Chem., 276:10358-10365, 2001 Cited by PubMed: 11121413 DOI: 10.1074/jbc.M009378200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation