4PH9

The structure of Ibuprofen bound to cyclooxygenase-2

Summary for 4PH9

Entry DOI	10.2210/pdb4ph9/pdb
Related	1EQG 3HS5 3NT1 3QMO
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	membrane protein, cyclooxygenase, cox, cox-2, ibuprofen, monotopic, prostaglandin, nsaid, oxidoreductase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	132637.56
Authors	Orlando, B.J.,Lucido, M.J.,Malkowski, M.G. (deposition date: 2014-05-05, release date: 2014-11-26, Last modification date: 2023-09-27)
Primary citation	Orlando, B.J.,Lucido, M.J.,Malkowski, M.G. The structure of ibuprofen bound to cyclooxygenase-2. J.Struct.Biol., 189:62-66, 2015 Cited by PubMed: 25463020 DOI: 10.1016/j.jsb.2014.11.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation