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1IGZ

Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

Summary for 1IGZ
Entry DOI10.2210/pdb1igz/pdb
Related1DIY 1FE2 1IGX
DescriptorProstaglandin Endoperoxide H Synthase-1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywordsmembrane protein, fatty acid, linoleic acid, oxidoreductase, peroxidase, dioxygenase
Biological sourceOvis aries (sheep)
Total number of polymer chains1
Total formula weight69589.35
Authors
Malkowski, M.G.,Thuresson, E.D.,Smith, W.L.,Garavito, R.M. (deposition date: 2001-04-18, release date: 2001-12-12, Last modification date: 2023-08-16)
Primary citationMalkowski, M.G.,Thuresson, E.D.,Lakkides, K.M.,Rieke, C.J.,Micielli, R.,Smith, W.L.,Garavito, R.M.
Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276:37547-37555, 2001
Cited by
PubMed: 11477109
DOI: 10.1074/jbc.M105982200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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