5F1A

The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2

Summary for 5F1A

• Entry DOI: 10.2210/pdb5f1a/pdb
• Related: 5F19
• Descriptor: Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: membrane protein, monotopic, cyclooxygenase, cyclooxygenase-2, cox, pghs, salicylic acid, salicylate, inhibitor, complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 131672.34

Authors

Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (deposition date: 2015-11-30, release date: 2016-03-16, Last modification date: 2020-07-29)

• Primary citation: Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G.; Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.; Biochemistry, 55:1226-1238, 2016; PubMed: 26859324; DOI: 10.1021/acs.biochem.5b01378

Experimental method

X-RAY DIFFRACTION (2.38 Å)