5F1A
The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Prostaglandin G/H synthase 2 | polymer | 553 | 63669.6 | 2 | UniProt (P35354) Pfam (PF03098) In PDB | Homo sapiens (Human) | Cyclooxygenase-2,COX-2,PHS II,Prostaglandin H2 synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2 |
| 2 | C | alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81874LD) | |||
| 3 | D | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | A, B | 2-HYDROXYBENZOIC ACID | non-polymer | 138.1 | 2 | Chemie (SAL) | |||
| 5 | A, B | PROTOPORPHYRIN IX CONTAINING CO | non-polymer | 619.6 | 2 | Chemie (COH) | |||
| 6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | A, B | ACRYLIC ACID | non-polymer | 72.1 | 3 | Chemie (AKR) | |||
| 8 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 9 | B | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 10 | water | water | 18.0 | 391 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 584 (UniProt: P35354)
| PDB | External Database | Details |
|---|---|---|
| Lys 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127339.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1335.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2997.9 | |
| All* | Total formula weight | 131672.3 |
