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5F1A

The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0001525biological_processangiogenesis
A0004601molecular_functionperoxidase activity
A0004666molecular_functionprostaglandin-endoperoxide synthase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005637cellular_componentnuclear inner membrane
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005789cellular_componentendoplasmic reticulum membrane
A0005901cellular_componentcaveola
A0006979biological_processresponse to oxidative stress
A0007566biological_processembryo implantation
A0007612biological_processlearning
A0007613biological_processmemory
A0008217biological_processregulation of blood pressure
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009624biological_processresponse to nematode
A0009750biological_processresponse to fructose
A0010042biological_processresponse to manganese ion
A0010269biological_processresponse to selenium ion
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0016020cellular_componentmembrane
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0019371biological_processcyclooxygenase pathway
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0030282biological_processbone mineralization
A0031394biological_processpositive regulation of prostaglandin biosynthetic process
A0031622biological_processpositive regulation of fever generation
A0031915biological_processpositive regulation of synaptic plasticity
A0032227biological_processnegative regulation of synaptic transmission, dopaminergic
A0032310biological_processprostaglandin secretion
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0033280biological_processresponse to vitamin D
A0034097biological_processresponse to cytokine
A0034605biological_processcellular response to heat
A0034612biological_processresponse to tumor necrosis factor
A0035633biological_processmaintenance of blood-brain barrier
A0042127biological_processregulation of cell population proliferation
A0042307biological_processpositive regulation of protein import into nucleus
A0042633biological_processhair cycle
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045786biological_processnegative regulation of cell cycle
A0045907biological_processpositive regulation of vasoconstriction
A0045986biological_processnegative regulation of smooth muscle contraction
A0045987biological_processpositive regulation of smooth muscle contraction
A0046697biological_processdecidualization
A0046872molecular_functionmetal ion binding
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0050873biological_processbrown fat cell differentiation
A0051213molecular_functiondioxygenase activity
A0051384biological_processresponse to glucocorticoid
A0051926biological_processnegative regulation of calcium ion transport
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0070542biological_processresponse to fatty acid
A0071222biological_processcellular response to lipopolysaccharide
A0071260biological_processcellular response to mechanical stimulus
A0071284biological_processcellular response to lead ion
A0071318biological_processcellular response to ATP
A0071456biological_processcellular response to hypoxia
A0071471biological_processcellular response to non-ionic osmotic stress
A0071498biological_processcellular response to fluid shear stress
A0071636biological_processpositive regulation of transforming growth factor beta production
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0090271biological_processpositive regulation of fibroblast growth factor production
A0090336biological_processpositive regulation of brown fat cell differentiation
A0090362biological_processpositive regulation of platelet-derived growth factor production
A0098869biological_processcellular oxidant detoxification
A0150077biological_processregulation of neuroinflammatory response
A1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
A1905375biological_processcellular response to homocysteine
A1990776biological_processresponse to angiotensin
B0001516biological_processprostaglandin biosynthetic process
B0001525biological_processangiogenesis
B0004601molecular_functionperoxidase activity
B0004666molecular_functionprostaglandin-endoperoxide synthase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005637cellular_componentnuclear inner membrane
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005789cellular_componentendoplasmic reticulum membrane
B0005901cellular_componentcaveola
B0006979biological_processresponse to oxidative stress
B0007566biological_processembryo implantation
B0007612biological_processlearning
B0007613biological_processmemory
B0008217biological_processregulation of blood pressure
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0009624biological_processresponse to nematode
B0009750biological_processresponse to fructose
B0010042biological_processresponse to manganese ion
B0010269biological_processresponse to selenium ion
B0010575biological_processpositive regulation of vascular endothelial growth factor production
B0016020cellular_componentmembrane
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0019371biological_processcyclooxygenase pathway
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0030282biological_processbone mineralization
B0031394biological_processpositive regulation of prostaglandin biosynthetic process
B0031622biological_processpositive regulation of fever generation
B0031915biological_processpositive regulation of synaptic plasticity
B0032227biological_processnegative regulation of synaptic transmission, dopaminergic
B0032310biological_processprostaglandin secretion
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0033280biological_processresponse to vitamin D
B0034097biological_processresponse to cytokine
B0034605biological_processcellular response to heat
B0034612biological_processresponse to tumor necrosis factor
B0035633biological_processmaintenance of blood-brain barrier
B0042127biological_processregulation of cell population proliferation
B0042307biological_processpositive regulation of protein import into nucleus
B0042633biological_processhair cycle
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045786biological_processnegative regulation of cell cycle
B0045907biological_processpositive regulation of vasoconstriction
B0045986biological_processnegative regulation of smooth muscle contraction
B0045987biological_processpositive regulation of smooth muscle contraction
B0046697biological_processdecidualization
B0046872molecular_functionmetal ion binding
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050727biological_processregulation of inflammatory response
B0050873biological_processbrown fat cell differentiation
B0051213molecular_functiondioxygenase activity
B0051384biological_processresponse to glucocorticoid
B0051926biological_processnegative regulation of calcium ion transport
B0051968biological_processpositive regulation of synaptic transmission, glutamatergic
B0070542biological_processresponse to fatty acid
B0071222biological_processcellular response to lipopolysaccharide
B0071260biological_processcellular response to mechanical stimulus
B0071284biological_processcellular response to lead ion
B0071318biological_processcellular response to ATP
B0071456biological_processcellular response to hypoxia
B0071471biological_processcellular response to non-ionic osmotic stress
B0071498biological_processcellular response to fluid shear stress
B0071636biological_processpositive regulation of transforming growth factor beta production
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0090271biological_processpositive regulation of fibroblast growth factor production
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090362biological_processpositive regulation of platelet-derived growth factor production
B0098869biological_processcellular oxidant detoxification
B0150077biological_processregulation of neuroinflammatory response
B1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
B1905375biological_processcellular response to homocysteine
B1990776biological_processresponse to angiotensin
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00298
ChainResidueDetails
AHIS207
BHIS207

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: For cyclooxygenase activity => ECO:0000250|UniProtKB:Q05769
ChainResidueDetails
ATYR385
BTYR385

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q05769
ChainResidueDetails
AARG120
ATYR355
BARG120
BTYR355

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00298
ChainResidueDetails
AHIS388
BHIS388

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Aspirin-acetylated serine => ECO:0000269|PubMed:26859324
ChainResidueDetails
ASER530
BSER530

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000305|PubMed:16373578
ChainResidueDetails
ACYS540
BCYS540

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: O-acetylserine => ECO:0000250|UniProtKB:Q05769
ChainResidueDetails
ASER579
BSER579

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26859324, ECO:0000269|PubMed:27226593, ECO:0007744|PDB:5F19, ECO:0007744|PDB:5F1A, ECO:0007744|PDB:5IKQ, ECO:0007744|PDB:5IKT
ChainResidueDetails
AASN68
BASN68

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26859324, ECO:0000269|PubMed:27226593, ECO:0000269|PubMed:27710942, ECO:0007744|PDB:5F19, ECO:0007744|PDB:5F1A, ECO:0007744|PDB:5IKQ, ECO:0007744|PDB:5IKR, ECO:0007744|PDB:5IKT, ECO:0007744|PDB:5IKV, ECO:0007744|PDB:5KIR
ChainResidueDetails
AASN144
AASN410
BASN144
BASN410

226707

PDB entries from 2024-10-30

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