5JVZ

Crystal structure of flurbiprofen bound to S121P murine COX-2 mutant

Summary for 5JVZ

Entry DOI	10.2210/pdb5jvz/pdb
Related	5JVY 5JW1
Descriptor	Prostaglandin G/H synthase 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	cyclooxygenase, cox-2, flurbiprofen, fbp, oxidoreductase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	131755.64
Authors	Malkowski, M.G.,Orlando, B.J. (deposition date: 2016-05-11, release date: 2016-10-26, Last modification date: 2023-09-27)
Primary citation	Dong, L.,Yuan, C.,Orlando, B.J.,Malkowski, M.G.,Smith, W.L. Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291:25641-25655, 2016 Cited by PubMed: 27756840 DOI: 10.1074/jbc.M116.757310 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation