Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 131 件

4M3Q
DownloadVisualize
BU of 4m3q by Molmil
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917
分子名称: CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ...
著者Zhang, W, Zhang, D, Stashko, M.A, DeRyckere, D, Hunter, D, Kireev, D.B, Miley, M, Cummings, C, Lee, M, Norris-Drouin, J, Stewart, W.M, Sather, S, Zhou, Y, Kirkpatrick, G, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X.
登録日2013-08-06
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.718 Å)
主引用文献Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4MHA
DownloadVisualize
BU of 4mha by Molmil
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817
分子名称: 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, CHLORIDE ION, MAGNESIUM ION, ...
著者Zhang, W, Mciver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, D.B.M, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, Dipaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X.
登録日2013-08-29
公開日2014-05-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
5T09
DownloadVisualize
BU of 5t09 by Molmil
The structure of the type III effector HopBA1
分子名称: CHLORIDE ION, POTASSIUM ION, Type III secretion system effector HopBA1
著者Cherkis, K, Machius, M, Nishimura, M.T, Dangl, J.L.
登録日2016-08-15
公開日2017-02-01
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (2.013 Å)
主引用文献TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4MH7
DownloadVisualize
BU of 4mh7 by Molmil
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896
分子名称: CHLORIDE ION, MAGNESIUM ION, N-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-methylpyrimidine-5-carboxamide, ...
著者Zhang, W, McIver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, M.J, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, DiPaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X.
登録日2013-08-29
公開日2014-05-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
3PJN
DownloadVisualize
BU of 3pjn by Molmil
The crystal structure of Tp34 bound to Zn(II) ion at pH 7.5
分子名称: 1,2-ETHANEDIOL, 34 kDa membrane antigen, SULFATE ION, ...
著者Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V.
登録日2010-11-10
公開日2011-11-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Characterization of the Tp34 lipoprotein from Treponema pallidum suggests a role in transition metal homeostasis
To be Published
4FID
DownloadVisualize
BU of 4fid by Molmil
Crystal structure of a heterotrimeric G-Protein subunit from entamoeba histolytica, EHG-ALPHA-1
分子名称: G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
著者Bosch, D.E, Kimple, A.J, Muller, R.E, Gigure, P.M, Willard, F.S, Machius, M, Temple, B.R, Siderovski, D.P.
登録日2012-06-08
公開日2012-11-28
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4GOU
DownloadVisualize
BU of 4gou by Molmil
Crystal structure of an RGS-RhoGEF from Entamoeba histolytica
分子名称: EhRGS-RhoGEF
著者Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P.
登録日2012-08-20
公開日2013-01-09
最終更新日2013-01-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
3PJL
DownloadVisualize
BU of 3pjl by Molmil
The crystal structure of Tp34 bound to Co (II) ion at pH 7.5
分子名称: 1,2-ETHANEDIOL, 34 kDa membrane antigen, COBALT (II) ION, ...
著者Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V.
登録日2010-11-10
公開日2011-11-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Characterization of the Tp34 lipoprotein from Treponema pallidum suggests a role in transition metal homeostasis
To be Published
2UXN
DownloadVisualize
BU of 2uxn by Molmil
Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation
分子名称: CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Yang, M, Culhane, J.C, Szewczuk, L.M, Gocke, C.B, Brautigam, C.A, Tomchick, D.R, Machius, M, Cole, P.A, Yu, H.
登録日2007-03-28
公開日2007-05-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
Nat.Struct.Mol.Biol., 14, 2007
2UXX
DownloadVisualize
BU of 2uxx by Molmil
Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
分子名称: CHLORIDE ION, FAD-trans-2-Phenylcyclopropylamine Adduct, GLYCEROL, ...
著者Yang, M, Culhane, J.C, Machius, M, Cole, P.A, Yu, H.
登録日2007-03-30
公開日2007-08-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.
Biochemistry, 46, 2007
6UCM
DownloadVisualize
BU of 6ucm by Molmil
Transcription factor DeltaFosB bZIP domain self-assembly, type-II crystal
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Protein fosB
著者Yin, Z, Machius, M, Rudenko, G.
登録日2019-09-16
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.424 Å)
主引用文献Self-assembly of the bZIP transcription factor Delta FosB.
Curr Res Struct Biol, 2, 2020
6UCL
DownloadVisualize
BU of 6ucl by Molmil
Transcription factor deltaFosB bZIP domain self-assembly, type-I crystal
分子名称: CHLORIDE ION, Protein fosB
著者Yin, Z, Machius, M, Rudenko, G.
登録日2019-09-16
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.207 Å)
主引用文献Self-assembly of the bZIP transcription factor Delta FosB.
Curr Res Struct Biol, 2, 2020
6UCI
DownloadVisualize
BU of 6uci by Molmil
Transcription factor DeltaFosB bZIP domain self-assembly, oxidized form
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Protein fosB
著者Yin, Z, Machius, M, Rudenko, G.
登録日2019-09-16
公開日2020-01-15
最終更新日2020-07-01
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Self-assembly of the bZIP transcription factor Delta FosB.
Curr Res Struct Biol, 2, 2020
3TCP
DownloadVisualize
BU of 3tcp by Molmil
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569
分子名称: 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CALCIUM ION, CHLORIDE ION, ...
著者Liu, J, Yang, C, Simpson, C, DeRyckere, D, Van Deusen, A, Miley, M, Kireev, D.B, Norris-Drouin, J, Sather, S, Hunter, D, Patel, H.S, Janzen, W.P, Machius, M, Johnson, G, Earp, H.S, Graham, D.K, Frye, S, Wang, X.
登録日2011-08-09
公開日2012-06-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
1U5B
DownloadVisualize
BU of 1u5b by Molmil
Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
分子名称: 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, GLYCEROL, ...
著者Wynn, R.M, Kato, M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T.
登録日2004-07-27
公開日2004-11-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
5C7O
DownloadVisualize
BU of 5c7o by Molmil
Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase holo form with NAD+
分子名称: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Betts, L, Machius, M, Danshina, P, O'Brien, D.
登録日2015-06-24
公開日2016-03-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.729 Å)
主引用文献Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
1KIL
DownloadVisualize
BU of 1kil by Molmil
Three-dimensional structure of the complexin/SNARE complex
分子名称: Complexin I SNARE-complex binding region, MAGNESIUM ION, SNAP-25 C-terminal SNARE motif, ...
著者Chen, X, Tomchick, D, Kovrigin, E, Arac, D, Machius, M, Sudhof, T.C, Rizo, J.
登録日2001-12-03
公開日2002-03-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three-dimensional structure of the complexin/SNARE complex.
Neuron, 33, 2002
2IW5
DownloadVisualize
BU of 2iw5 by Molmil
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
分子名称: AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H.
登録日2006-06-26
公開日2006-08-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase
Mol.Cell, 23, 2006
5C7L
DownloadVisualize
BU of 5c7l by Molmil
Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form
分子名称: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
著者Betts, L, Machius, M, Danshina, P, O'Brien, D.
登録日2015-06-24
公開日2016-03-09
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (1.862 Å)
主引用文献Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
1JPZ
DownloadVisualize
BU of 1jpz by Molmil
Crystal structure of a complex of the heme domain of P450BM-3 with N-Palmitoylglycine
分子名称: BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE, N-PALMITOYLGLYCINE, PROTOPORPHYRIN IX CONTAINING FE
著者Haines, D.C, Tomchick, D.R, Machius, M, Peterson, J.A.
登録日2001-08-03
公開日2001-11-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Pivotal role of water in the mechanism of P450BM-3.
Biochemistry, 40, 2001
3ONW
DownloadVisualize
BU of 3onw by Molmil
Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif.
分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ...
著者Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P.
登録日2010-08-30
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
2LCH
DownloadVisualize
BU of 2lch by Molmil
Solution NMR Structure of a Protein With a Redesigned Hydrophobic Core, Northeast Structural Genomics Consortium Target OR38
分子名称: Protein OR38
著者Mills, J.L, Murphy, G, Miley, M, Machius, M, Kuhlman, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG)
登録日2011-04-29
公開日2011-05-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of a Protein With a Redesigned Hydrophobic Core, Northeast Structural Genomics Consortium Target OR38
To be Published
5V5V
DownloadVisualize
BU of 5v5v by Molmil
Complex of NLGN2 with MDGA1 Ig1-Ig2
分子名称: MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-2
著者Gangwar, S.P, Machius, M, Rudenko, G.
登録日2017-03-15
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.11 Å)
主引用文献Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Neuron, 94, 2017
3U3B
DownloadVisualize
BU of 3u3b by Molmil
Crystal Structure of Computationally Redesigned Four-Helix Bundle
分子名称: computationally designed four-helix bundle protein
著者Murphy, G.S, Machius, M.
登録日2011-10-05
公開日2012-06-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core.
Structure, 20, 2012
2VFX
DownloadVisualize
BU of 2vfx by Molmil
Structure of the Symmetric Mad2 Dimer
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ...
著者Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X.
登録日2007-11-05
公開日2008-03-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
Plos Biol., 6, 2008

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon