5C7L

Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form

Summary for 5C7L

• Entry DOI: 10.2210/pdb5c7l/pdb
• Related: 5C7O
• Descriptor: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (2 entities in total)
• Functional Keywords: human sperm gapdh metabolic enzyme sperm specific, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 73477.52

Authors

Betts, L.,Machius, M.,Danshina, P.,O'Brien, D. (deposition date: 2015-06-24, release date: 2016-03-09, Last modification date: 2025-04-02)

Primary citation

Danshina, P.V.,Qu, W.,Temple, B.R.,Rojas, R.J.,Miley, M.J.,Machius, M.,Betts, L.,O'Brien, D.A.
Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22:410-426, 2016

PubMed Abstract: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.

PubMed: 26921398
DOI: 10.1093/molehr/gaw016

Experimental method

X-RAY DIFFRACTION (1.862 Å)