3TCP
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569
Summary for 3TCP
Entry DOI | 10.2210/pdb3tcp/pdb |
Related | 2BRB 2POC 3BPR |
Descriptor | Tyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | tyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type I membrane protein : Q12866 |
Total number of polymer chains | 2 |
Total formula weight | 72798.47 |
Authors | Liu, J.,Yang, C.,Simpson, C.,DeRyckere, D.,Van Deusen, A.,Miley, M.,Kireev, D.B.,Norris-Drouin, J.,Sather, S.,Hunter, D.,Patel, H.S.,Janzen, W.P.,Machius, M.,Johnson, G.,Earp, H.S.,Graham, D.K.,Frye, S.,Wang, X. (deposition date: 2011-08-09, release date: 2012-06-20, Last modification date: 2023-09-13) |
Primary citation | Liu, J.,Yang, C.,Simpson, C.,Deryckere, D.,Van Deusen, A.,Miley, M.J.,Kireev, D.,Norris-Drouin, J.,Sather, S.,Hunter, D.,Korboukh, V.K.,Patel, H.S.,Janzen, W.P.,Machius, M.,Johnson, G.L.,Earp, H.S.,Graham, D.K.,Frye, S.V.,Wang, X. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett, 3:129-134, 2012 Cited by PubMed: 22662287PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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