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3TCP

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTyrosine-protein kinase Merpolymer31335889.42UniProt (Q12866)
Pfam (PF07714)
In PDB
Homo sapiens (human)Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK
2A, B1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-aminenon-polymer396.52Chemie (CKJ)
3A, BCHLORIDE IONnon-polymer35.53Chemie (CL)
4A, BCALCIUM IONnon-polymer40.13Chemie (CA)
5waterwater18.036Chemie (HOH)
Sequence modifications
A, B: 570 - 864 (UniProt: Q12866)
PDBExternal DatabaseDetails
Met 552-expression tag
Gly 553-expression tag
Ser 554-expression tag
Ser 555-expression tag
His 556-expression tag
His 557-expression tag
His 558-expression tag
His 559-expression tag
His 560-expression tag
His 561-expression tag
Ser 562-expression tag
Ser 563-expression tag
Gly 564-expression tag
Leu 565-expression tag
Val 566-expression tag
Pro 567-expression tag
Arg 568-expression tag
Gly 569-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight71778.9
Non-Polymers*Number of molecules8
Total formula weight1019.6
All*Total formula weight72798.5
*Water molecules are not included.

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PDB entries from 2024-03-27

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