2UXN

Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation

Summary for 2UXN

Related2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2COM 2H94 2IW5 2UXX
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3.1, ... (7 entities in total)
Functional Keywordsoxidoreductase-transcription regulator complex, oxidoreductase-repressor complex, histone demethylase, fad, lsd1, corest, repressor, transcription regulation, host-virus interaction, chromatin demethylation, nuclear protein, phosphorylation, chromatin regulator, nucleosomes, transcription, oxidoreductase, oxidoreductase/transcription regulator
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus O60341 Q9UKL0 P68431
Total number of polymer chains3
Total molecular weight103819.83
Authors
Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Gocke, C.B.,Brautigam, C.A.,Tomchick, D.R.,Machius, M.,Cole, P.A.,Yu, H. (deposition date: 2007-03-28, release date: 2007-05-29, Last modification date: 2011-07-13)
Primary citation
Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Gocke, C.B.,Brautigam, C.A.,Tomchick, D.R.,Machius, M.,Cole, P.A.,Yu, H.
Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
Nat.Struct.Mol.Biol., 14:535-, 2007
PubMed: 17529991 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB1255
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.72 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24920.4%2.6%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report