2UXX
Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
Summary for 2UXX
Entry DOI | 10.2210/pdb2uxx/pdb |
Related | 2COM 2H94 2IW5 2UXN |
Descriptor | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FAD-trans-2-Phenylcyclopropylamine Adduct, ... (6 entities in total) |
Functional Keywords | oxidoreductase-repressor complex, histone demethylase, oxidoreductase, nuclear protein, phosphorylation, transcription regulation, tranylcypromine, chromatin regulator, nucleosomes, transcription, host-virus interaction, chromatin demethylation, fad, lsd1, corest, repressor, depression, oxidoreductase/repressor |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 101691.88 |
Authors | Yang, M.,Culhane, J.C.,Machius, M.,Cole, P.A.,Yu, H. (deposition date: 2007-03-30, release date: 2007-08-21, Last modification date: 2024-05-08) |
Primary citation | Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Jalili, P.,Ball, H.L.,Machius, M.,Cole, P.A.,Yu, H. Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine. Biochemistry, 46:8058-, 2007 Cited by PubMed: 17569509DOI: 10.1021/BI700664Y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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