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2UXX

Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct

Summary for 2UXX
Entry DOI10.2210/pdb2uxx/pdb
Related2COM 2H94 2IW5 2UXN
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FAD-trans-2-Phenylcyclopropylamine Adduct, ... (6 entities in total)
Functional Keywordsoxidoreductase-repressor complex, histone demethylase, oxidoreductase, nuclear protein, phosphorylation, transcription regulation, tranylcypromine, chromatin regulator, nucleosomes, transcription, host-virus interaction, chromatin demethylation, fad, lsd1, corest, repressor, depression, oxidoreductase/repressor
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains2
Total formula weight101691.88
Authors
Yang, M.,Culhane, J.C.,Machius, M.,Cole, P.A.,Yu, H. (deposition date: 2007-03-30, release date: 2007-08-21, Last modification date: 2019-02-06)
Primary citationYang, M.,Culhane, J.C.,Szewczuk, L.M.,Jalili, P.,Ball, H.L.,Machius, M.,Cole, P.A.,Yu, H.
Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.
Biochemistry, 46:8058-, 2007
Cited by
PubMed: 17569509
DOI: 10.1021/BI700664Y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.74 Å)
Structure validation

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