Crystal Structure of Computationally Redesigned Four-Helix Bundle

Summary for 3U3B

Related1TQG 2LCH
Descriptorcomputationally designed four-helix bundle protein (2 entities in total)
Functional Keywordsfour-helix bundle, flexible backbone protein design, hyperthermostable, unknown function
Biological sourcesynthetic construct
Total number of polymer chains2
Total molecular weight26532.9
Murphy, G.S.,Machius, M. (deposition date: 2011-10-05, release date: 2012-06-13, Last modification date: 2017-11-08)
Primary citation
Murphy, G.S.,Mills, J.L.,Miley, M.J.,Machius, M.,Szyperski, T.,Kuhlman, B.
Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core.
Structure, 20:1086-1096, 2012
PubMed: 22632833 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2012.03.026
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197601.0%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution