1VF2
 
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3MOP
 | | The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88 | | Authors: | Lin, S.-C, Lo, Y.-C, Wu, H. | | Deposit date: | 2010-04-23 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Nature, 465, 2010
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8XR2
 | | Crystal structure of AKRtyl-apo1 | | Descriptor: | Aldo/keto reductase | | Authors: | Lin, S, Dai, S, Xiao, Z. | | Deposit date: | 2024-01-06 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8XR4
 | | Crystal structure of AKRtyl-NADP(H) complex | | Descriptor: | Aldo/keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Lin, S, Dai, S, Xiao, Z. | | Deposit date: | 2024-01-06 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8YD8
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8YBX
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8XR3
 | | Crystal structure of AKRtyl-apo2 | | Descriptor: | Aldo/keto reductase | | Authors: | Lin, S, Dai, S, Xiao, Z. | | Deposit date: | 2024-01-06 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8YD7
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7DIY
 | | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | | Descriptor: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | | Authors: | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | | Deposit date: | 2020-11-19 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.693 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.
Nucleic Acids Res., 49, 2021
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7YTU
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7YTT
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1MUC
 | | STRUCTURE OF MUCONATE LACTONIZING ENZYME AT 1.85 ANGSTROMS RESOLUTION | | Descriptor: | MANGANESE (II) ION, MUCONATE LACTONIZING ENZYME | | Authors: | Helin, S, Kahn, P.C, Guha, B.H.L, Mallows, D.J, Goldman, A. | | Deposit date: | 1995-09-20 | | Release date: | 1996-07-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida PRS2000 at 1.85 A resolution.
J.Mol.Biol., 254, 1995
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5WVC
 | | Structure of the CARD-CARD disk | | Descriptor: | Apoptotic protease-activating factor 1, Caspase, IODIDE ION | | Authors: | Lin, S.C, Lo, Y.C, Su, T.W. | | Deposit date: | 2016-12-24 | | Release date: | 2017-04-19 | | Method: | X-RAY DIFFRACTION (2.993 Å) | | Cite: | Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.
Structure, 25, 2017
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8JBQ
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7C2J
 | | Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization) | | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | | Deposit date: | 2020-05-07 | | Release date: | 2020-05-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.799 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.
Signal Transduct Target Ther, 5, 2020
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7C2I
 | | Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization) | | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | | Deposit date: | 2020-05-07 | | Release date: | 2020-05-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.
Signal Transduct Target Ther, 5, 2020
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1VCY
 | | VVA2 isoform | | Descriptor: | MALONATE ION, volvatoxin A2 | | Authors: | Lin, S.-C, Lo, Y.-C, Lin, J.-Y, Liaw, Y.-C. | | Deposit date: | 2004-03-17 | | Release date: | 2004-10-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures and electron micrographs of fungal volvatoxin A2
J.Mol.Biol., 343, 2004
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1VGF
 | | volvatoxin A2 (diamond crystal form) | | Descriptor: | ACETATE ION, volvatoxin A2 | | Authors: | Lin, S.-C, Lo, Y.-C, Lin, J.-Y, Liaw, Y.-C. | | Deposit date: | 2004-04-24 | | Release date: | 2004-10-05 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures and electron micrographs of fungal volvatoxin A2
J.Mol.Biol., 343, 2004
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3D3J
 | | Crystal structure of human Edc3p | | Descriptor: | Enhancer of mRNA-decapping protein 3 | | Authors: | Ling, S.H.M. | | Deposit date: | 2008-05-12 | | Release date: | 2008-08-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of human Edc3 and its functional implications
Mol.Cell.Biol., 28, 2008
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4WID
 | | Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration) | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, RhUL123 | | Authors: | Klingl, S, Scherer, M, Sevvana, M, Muller, Y.A, Stamminger, T. | | Deposit date: | 2014-09-25 | | Release date: | 2014-10-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions.
Plos Pathog., 10, 2014
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4WIC
 | | Immediate-early 1 protein (IE1) of rhesus macaque cytomegalovirus | | Descriptor: | RhUL123 | | Authors: | Klingl, S, Scherer, M, Sevvana, M, Muller, Y.A, Stamminger, T. | | Deposit date: | 2014-09-25 | | Release date: | 2015-07-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Controlled crystal dehydration triggers a space-group switch and shapes the tertiary structure of cytomegalovirus immediate-early 1 (IE1) protein.
Acta Crystallogr.,Sect.D, 71, 2015
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8JWO
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8JWM
 | | Crystal structure of AKRtyl-NADP-tylosin complex | | Descriptor: | Aldo/keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TYLOSIN | | Authors: | Lin, S, Dai, S, Xiao, Z. | | Deposit date: | 2023-06-29 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8JWK
 | | The second purified state crystal structure of AKRtyl | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Lin, S, Dai, S, Xiao, Z. | | Deposit date: | 2023-06-29 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8JWL
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