3MOP

The ternary Death Domain complex of MyD88, IRAK4, and IRAK2

Summary for 3MOP

• Entry DOI: 10.2210/pdb3mop/pdb
• Descriptor: Myeloid differentiation primary response protein MyD88, Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2 (3 entities in total)
• Functional Keywords: death domain complex, helical symmetry, single-stranded helical assembly, left-handed helical assembly, signaling protein, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : Q99836 Q9NWZ3
• Total number of polymer chains: 14
• Total formula weight: 179456.19

Authors

Lin, S.-C.,Lo, Y.-C.,Wu, H. (deposition date: 2010-04-23, release date: 2010-06-02, Last modification date: 2024-02-21)

• Primary citation: Lin, S.C.,Lo, Y.C.,Wu, H.; Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.; Nature, 465:885-890, 2010; PubMed: 20485341; DOI: 10.1038/nature09121

Experimental method

X-RAY DIFFRACTION (3.4 Å)