3MOP

The ternary Death Domain complex of MyD88, IRAK4, and IRAK2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
A	0007165	biological_process	signal transduction
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0070976	molecular_function	TIR domain binding
B	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
B	0007165	biological_process	signal transduction
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0070976	molecular_function	TIR domain binding
C	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
C	0007165	biological_process	signal transduction
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0070976	molecular_function	TIR domain binding
D	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
D	0007165	biological_process	signal transduction
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0070976	molecular_function	TIR domain binding
E	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
E	0007165	biological_process	signal transduction
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0070976	molecular_function	TIR domain binding
F	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
F	0007165	biological_process	signal transduction
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0070976	molecular_function	TIR domain binding
K	0007165	biological_process	signal transduction
L	0007165	biological_process	signal transduction
M	0007165	biological_process	signal transduction
N	0007165	biological_process	signal transduction

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	330
Details	Domain: {"description":"Death","evidences":[{"source":"PROSITE-ProRule","id":"PRU00064","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	660
Details	Domain: {"description":"Death"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---