3MOP

The ternary Death Domain complex of MyD88, IRAK4, and IRAK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Myeloid differentiation primary response protein MyD88	polymer	110	12581.4	6	UniProt (Q99836) Pfam (PF00531)	Homo sapiens (human)
2	G, H, I, J (G, H, I, J)	Interleukin-1 receptor-associated kinase 4	polymer	113	12804.6	4	UniProt (Q9NWZ3)	Homo sapiens (human)	IRAK-4, Renal carcinoma antigen NY-REN-64
3	K, L, M, N (K, L, M, N)	Interleukin-1 receptor-associated kinase-like 2	polymer	111	13187.4	4	UniProt (O43187) Pfam (PF00531)	Homo sapiens (human)	IRAK-2

Sequence modifications

A, B, C, D, E, F: 20 - 117 (UniProt: Q99836)

PDB	External Database	Details
Met 19	-	expression tag
Ala 118	-	expression tag
Ala 119	-	expression tag
Ala 120	-	expression tag
Leu 121	-	expression tag
Glu 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag

G, H, I, J: 4 - 106 (UniProt: Q9NWZ3)

PDB	External Database	Details
Met 2	-	expression tag
Gly 3	-	expression tag
Leu 107	-	expression tag
Glu 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag

K, L, M, N: 2 - 112 (UniProt: O43187)

PDB	External Database	Details
Trp 50	Arg 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	179456.2
All*	Total formula weight	179456.2

*Water molecules are not included.