7C2J

Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization)

Summary for 7C2J

• Entry DOI: 10.2210/pdb7c2j/pdb
• Descriptor: 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• Functional Keywords: 2'-o-methylase, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 2
• Total formula weight: 50058.96

Authors

Lin, S.,Chen, H.,Ye, F.,Chen, Z.M.,Yang, F.L.,Zheng, Y.,Cao, Y.,Qiao, J.X.,Yang, S.Y.,Lu, G.W. (deposition date: 2020-05-07, release date: 2020-05-27, Last modification date: 2023-11-29)

• Primary citation: Lin, S.,Chen, H.,Ye, F.,Chen, Z.,Yang, F.,Zheng, Y.,Cao, Y.,Qiao, J.,Yang, S.,Lu, G.; Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.; Signal Transduct Target Ther, 5:131-131, 2020; PubMed: 32728018; DOI: 10.1038/s41392-020-00241-4

Experimental method

X-RAY DIFFRACTION (2.799 Å)