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7C2J

Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
B0003723molecular_functionRNA binding
B0008270molecular_functionzinc ion binding
B0019079biological_processviral genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue SAM A 301
ChainResidue
AASN43
AASN101
ACYS115
AASP130
AMET131
ATYR132
APHE149
AHOH404
AHOH409
ATYR47
AGLY71
AGLY73
ASER74
APRO80
AGLY81
AASP99
ALEU100

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN B 201
ChainResidue
BCYS117
BCYS120
BCYS128
BCYS130

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN B 202
ChainResidue
BCYS74
BCYS77
BHIS83
BCYS90

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01297
ChainResidueDetails
BCYS74
BCYS77
BHIS83
BCYS90
BCYS117
BCYS120
BCYS128
BCYS130

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
BGLN139

226707

PDB entries from 2024-10-30

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