7K1D
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![BU of 7k1d by Molmil](/molmil-images/mine/7k1d) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_77291 | 分子名称: | (3R)-3-{4-[(3R)-4-(3,4-difluorobenzene-1-carbonyl)morpholin-3-yl]-1H-1,2,3-triazol-1-yl}-N-hydroxy-4-(naphthalen-2-yl)butanamide, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 2 To Be Published
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7K1F
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![BU of 7k1f by Molmil](/molmil-images/mine/7k1f) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88558 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 4 To Be Published
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7K1E
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![BU of 7k1e by Molmil](/molmil-images/mine/7k1e) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3 To Be Published
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3OVP
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![BU of 3ovp by Molmil](/molmil-images/mine/3ovp) | Crystal Structure of hRPE | 分子名称: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, FE (II) ION, Ribulose-phosphate 3-epimerase | 著者 | Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J. | 登録日 | 2010-09-16 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE Faseb J., 25, 2011
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3OVQ
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![BU of 3ovq by Molmil](/molmil-images/mine/3ovq) | Crystal Structure of hRPE and D-Ribulose-5-Phospate Complex | 分子名称: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, FE (II) ION, RIBULOSE-5-PHOSPHATE, ... | 著者 | Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J. | 登録日 | 2010-09-17 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE Faseb J., 25, 2011
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3OVR
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![BU of 3ovr by Molmil](/molmil-images/mine/3ovr) | Crystal Structure of hRPE and D-Xylulose 5-Phosphate Complex | 分子名称: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, 5-O-phosphono-D-xylulose, FE (II) ION, ... | 著者 | Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J. | 登録日 | 2010-09-17 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | 主引用文献 | Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE Faseb J., 25, 2011
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5L2U
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![BU of 5l2u by Molmil](/molmil-images/mine/5l2u) | |
5DNF
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![BU of 5dnf by Molmil](/molmil-images/mine/5dnf) | Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, C-C motif chemokine 5, ... | 著者 | Liang, W.G, Tang, W. | 登録日 | 2015-09-10 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc.Natl.Acad.Sci.USA, 113, 2016
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5D65
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![BU of 5d65 by Molmil](/molmil-images/mine/5d65) | X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-C motif chemokine 3, CHLORIDE ION, ... | 著者 | Liang, W.G, Hwang, D.Y, Zulueta, M.M, Hung, S.C, Tang, W. | 登録日 | 2015-08-11 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc.Natl.Acad.Sci.USA, 113, 2016
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4NXO
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![BU of 4nxo by Molmil](/molmil-images/mine/4nxo) | Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768 | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Deprez, B, Tang, W. | 登録日 | 2013-12-09 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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4IFH
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![BU of 4ifh by Molmil](/molmil-images/mine/4ifh) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 | 分子名称: | Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION | 著者 | Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W. | 登録日 | 2012-12-14 | 公開日 | 2013-12-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.286 Å) | 主引用文献 | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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4MHE
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![BU of 4mhe by Molmil](/molmil-images/mine/4mhe) | Crystal structure of CC-chemokine 18 | 分子名称: | ACETATE ION, C-C motif chemokine 18 | 著者 | Liang, W.G, Tang, W.-J. | 登録日 | 2013-08-29 | 公開日 | 2014-09-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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6AIB
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![BU of 6aib by Molmil](/molmil-images/mine/6aib) | Crystal structures of the N-terminal RecA-like domain 1 of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA | 分子名称: | DEAD-box ATP-dependent RNA helicase CshA | 著者 | Chengliang, W, Tian, T, Xiaobao, C, Xuan, Z, Jianye, Z. | 登録日 | 2018-08-22 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP Acta Crystallogr F Struct Biol Commun, 74, 2018
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4M1L
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![BU of 4m1l by Molmil](/molmil-images/mine/4m1l) | Complex of IQCG and Ca2+-bound CaM | 分子名称: | CALCIUM ION, Calmodulin, IQ domain-containing protein G, ... | 著者 | Liang, W.X, Chen, L.T, Chen, Z, Chen, S.J, Chen, S. | 登録日 | 2013-08-03 | 公開日 | 2014-05-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish Nat Commun, 5, 2014
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4LZX
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![BU of 4lzx by Molmil](/molmil-images/mine/4lzx) | Complex of IQCG and Ca2+-free CaM | 分子名称: | Calmodulin, IQ domain-containing protein G, SULFATE ION | 著者 | Liang, W.X, Chen, L.T, Chen, Z, Chen, S.J, Chen, S. | 登録日 | 2013-08-01 | 公開日 | 2014-05-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish Nat Commun, 5, 2014
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1NM8
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![BU of 1nm8 by Molmil](/molmil-images/mine/1nm8) | Structure of Human Carnitine Acetyltransferase: Molecular Basis for Fatty Acyl Transfer | 分子名称: | Carnitine O-acetyltransferase | 著者 | Wu, D, Govindasamy, L, Lian, W, Gu, Y, Kukar, T, Agbandje-McKenna, M, McKenna, R. | 登録日 | 2003-01-09 | 公開日 | 2003-03-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of Human Carnitine Acetyltransferase. Molecular Basis for Fatty Acyl Transfer J.Biol.Chem., 278, 2003
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1I1I
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![BU of 1i1i by Molmil](/molmil-images/mine/1i1i) | NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE | 分子名称: | NEUROLYSIN, ZINC ION | 著者 | Brown, C.K, Madauss, K, Lian, W, Tolbert, W.D, Beck, M.R, Rodgers, D.W. | 登録日 | 2001-02-01 | 公開日 | 2001-02-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of neurolysin reveals a deep channel that limits substrate access. Proc.Natl.Acad.Sci.USA, 98, 2001
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1S5O
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![BU of 1s5o by Molmil](/molmil-images/mine/1s5o) | Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase | 分子名称: | CARNITINE, carnitine acetyltransferase isoform 2 | 著者 | Govindasamy, L, Kukar, T, Lian, W, Pedersen, B, Gu, Y, Agbandje-Mckenna, M, Jin, S, Mckenna, R, Wu, D. | 登録日 | 2004-01-21 | 公開日 | 2004-02-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase. J.Struct.Biol., 146, 2004
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1T1U
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![BU of 1t1u by Molmil](/molmil-images/mine/1t1u) | Structural Insights and Functional Implications of Choline Acetyltransferase | 分子名称: | Choline O-acetyltransferase | 著者 | Govindasamy, L, Pedersen, B, Lian, W, Kukar, T, Gu, Y, Jin, S, Agbandje-McKenna, M, Wu, D. | 登録日 | 2004-04-18 | 公開日 | 2005-04-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural insights and functional implications of choline acetyltransferase J.Struct.Biol., 148, 2004
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3UX9
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![BU of 3ux9 by Molmil](/molmil-images/mine/3ux9) | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus | 分子名称: | Interferon alpha-1/13, ScFv antibody | 著者 | Ouyang, S, Zhao, L.X, Liang, W, Shaw, N, Liu, Z.-J, Liang, M.-F. | 登録日 | 2011-12-04 | 公開日 | 2012-02-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus J.Mol.Med., 2012
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7C6P
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![BU of 7c6p by Molmil](/molmil-images/mine/7c6p) | Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 | 著者 | Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. | 登録日 | 2020-05-22 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
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6PET
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![BU of 6pet by Molmil](/molmil-images/mine/6pet) | Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha | 分子名称: | (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, CHLORIDE ION, ... | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Wang, X, Zbieg, J, Labadie, S.S, Zhang, B, Li, J, Liang, W. | 登録日 | 2019-06-20 | 公開日 | 2019-07-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29, 2019
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4RPU
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![BU of 4rpu by Molmil](/molmil-images/mine/4rpu) | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 | 分子名称: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | 著者 | Mo, S.M, Liang, W.G, King, J.V, Wijaya, J, Koehler, C.M, Tang, W.J. | 登録日 | 2014-10-31 | 公開日 | 2015-12-09 | 実験手法 | X-RAY DIFFRACTION (2.265 Å) | 主引用文献 | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 TO BE PUBLISHED
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2D2D
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![BU of 2d2d by Molmil](/molmil-images/mine/2d2d) | Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor I2 | 分子名称: | 3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE | 著者 | Yang, H, Bartlam, M, Xue, X, Yang, K, Liang, W, Ding, Y, Rao, Z. | 登録日 | 2005-09-08 | 公開日 | 2005-09-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. Plos Biol., 3, 2005
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7K1V
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![BU of 7k1v by Molmil](/molmil-images/mine/7k1v) | |