6PET
Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha
Summary for 6PET
| Entry DOI | 10.2210/pdb6pet/pdb |
| Descriptor | Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, ... (6 entities in total) |
| Functional Keywords | hormone receptor, ligand, breast cancer, drug, antagonist, nuclear protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 129870.36 |
| Authors | Kiefer, J.R.,Vinogradova, M.,Liang, J.,Wang, X.,Zbieg, J.,Labadie, S.S.,Zhang, B.,Li, J.,Liang, W. (deposition date: 2019-06-20, release date: 2019-07-17, Last modification date: 2024-04-03) |
| Primary citation | Labadie, S.S.,Li, J.,Blake, R.A.,Chang, J.H.,Goodacre, S.,Hartman, S.J.,Liang, W.,Kiefer, J.R.,Kleinheinz, T.,Lai, T.,Liao, J.,Ortwine, D.F.,Mody, V.,Ray, N.C.,Roussel, F.,Vinogradova, M.,Yeap, S.K.,Zhang, B.,Zheng, X.,Zbieg, J.R.,Liang, J.,Wang, X. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29:2090-2093, 2019 Cited by PubMed Abstract: Phenolic groups are responsible for the high clearance and low oral bioavailability of the estrogen receptor alpha (ERα) clinical candidate GDC-0927. An exhaustive search for a backup molecule with improved pharmacokinetic (PK) properties identified several metabolically stable analogs, although in general at the expense of the desired potency and degradation efficiency. C-8 hydroxychromene 30 is the first example of a phenol-containing chromene that not only maintained excellent potency but also exhibited 10-fold higher oral exposure in rats. The improved in vivo clearance in rat was hypothesized to be the result of C-8 hydroxy group being sterically protected from glucuronide conjugation. The excellent potency underscores the possibility of replacing the presumed indispensable phenolic group at C-6 or C-7 of the chromene core. Co-crystal structures were obtained to highlight the change in key interactions and rationalize the retained potency. PubMed: 31311734DOI: 10.1016/j.bmcl.2019.07.013 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.203 Å) |
Structure validation
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