1S5O

Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase

Summary for 1S5O

Entry DOI	10.2210/pdb1s5o/pdb
Descriptor	carnitine acetyltransferase isoform 2, CARNITINE (3 entities in total)
Functional Keywords	carnitine acetyltransferase, binary complex, steady-state enzyme kinetics, substrate binding site, transferase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum (Potential). Isoform 1: Mitochondrion (Potential). Isoform 2: Peroxisome (Potential): P43155
Total number of polymer chains	1
Total formula weight	70065.07
Authors	Govindasamy, L.,Kukar, T.,Lian, W.,Pedersen, B.,Gu, Y.,Agbandje-Mckenna, M.,Jin, S.,Mckenna, R.,Wu, D. (deposition date: 2004-01-21, release date: 2004-02-03, Last modification date: 2023-08-23)
Primary citation	Govindasamy, L.,Kukar, T.,Lian, W.,Pedersen, B.,Gu, Y.,Agbandje-McKenna, M.,Jin, S.,McKenna, R.,Wu, D. Structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase. J.Struct.Biol., 146:416-424, 2004 Cited by PubMed: 15099582 DOI: 10.1016/j.jsb.2004.01.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation