1S5O

Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003997	molecular_function	acyl-CoA oxidase activity
A	0004092	molecular_function	carnitine O-acetyltransferase activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0008458	molecular_function	carnitine O-octanoyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019254	biological_process	carnitine metabolic process, CoA-linked
A	0033540	biological_process	fatty acid beta-oxidation using acyl-CoA oxidase
A	0046459	biological_process	short-chain fatty acid metabolic process
A	0051791	biological_process	medium-chain fatty acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 152 A 617

Chain	Residue
A	TRP81
A	HIS322
A	GLU326
A	TYR431
A	SER433
A	THR444
A	SER531
A	PHE545
A	HOH638

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Functional Information from PROSITE/UniProt

site_id	PS00439
Number of Residues	16
Details	ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPrLPVPpLqQSLdhY

Chain	Residue	Details
A	LEU14-TYR29

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site_id	PS00440
Number of Residues	28
Details	ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWfDKtLqFIvaeDGscglvyEHaaaEG

Chain	Residue	Details
A	ARG300-GLY327

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305

Chain	Residue	Details
A	LYS343

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P47934

Chain	Residue	Details
A	ALA419
A	ILE423
A	THR456
A	LEU504
A	VAL555

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15099582

Chain	Residue	Details
A	MET452
A	SER454
A	SER465

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P47934

Chain	Residue	Details
A	VAL93

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P47934

Chain	Residue	Details
A	SER261

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	ASP268

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1q6x

Chain	Residue	Details
A	HIS322
A	TYR86
A	SER533
A	PRO99

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1q6x

Chain	Residue	Details
A	HIS322
A	SER533

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