3UX9

Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

Summary for 3UX9

Entry DOI	10.2210/pdb3ux9/pdb
Descriptor	Interferon alpha-1/13, ScFv antibody (3 entities in total)
Functional Keywords	five helices, long loop connecting helix, hydrophobic interactions, cytokine-immune system complex, cytokine/immune system
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01562
Total number of polymer chains	4
Total formula weight	93994.74
Authors	Ouyang, S.,Zhao, L.X.,Liang, W.,Shaw, N.,Liu, Z.-J.,Liang, M.-F. (deposition date: 2011-12-04, release date: 2012-02-29)
Primary citation	Ouyang, S.,Gong, B.,Li, J.-Z.,Zhao, L.-X.,Wu, W.,Zhang, F.-S.,Sun, L.,Wang, S.-J.,Pan, M.,Li, C.,Liang, W.,Shaw, N.,Zheng, J.,Zhao, G.-P.,Wang, Y.,Liu, Z.-J.,Liang, M.-F. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus J.Mol.Med., 2012 Cited by PubMed: 22307521 DOI: 10.1007/s00109-012-0866-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation