3UX9

Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002286	biological_process	T cell activation involved in immune response
A	0002312	biological_process	B cell activation involved in immune response
A	0002323	biological_process	natural killer cell activation involved in immune response
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005132	molecular_function	type I interferon receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006952	biological_process	defense response
A	0006959	biological_process	humoral immune response
A	0043330	biological_process	response to exogenous dsRNA
A	0046718	biological_process	symbiont entry into host cell
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0098586	biological_process	cellular response to virus
A	0140374	biological_process	antiviral innate immune response
C	0002250	biological_process	adaptive immune response
C	0002286	biological_process	T cell activation involved in immune response
C	0002312	biological_process	B cell activation involved in immune response
C	0002323	biological_process	natural killer cell activation involved in immune response
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005132	molecular_function	type I interferon receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006952	biological_process	defense response
C	0006959	biological_process	humoral immune response
C	0043330	biological_process	response to exogenous dsRNA
C	0046718	biological_process	symbiont entry into host cell
C	0051607	biological_process	defense response to virus
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0098586	biological_process	cellular response to virus
C	0140374	biological_process	antiviral innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFrRItlYLtekkyspCAW

Chain	Residue	Details
A	TYR123-TRP141

---