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PDB: 93 件

8TZ8
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Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT3 conformation
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
著者Wright, N.J, Lee, S.-Y.
登録日2023-08-26
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
5U9W
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Structure of CNTnw N149L in the intermediate 3 state
分子名称: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease
著者Hirschi, M, Johnson, Z.L, Lee, S.-Y.
登録日2016-12-18
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.555 Å)
主引用文献Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
7TX7
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Cryo-EM structure of the human reduced folate carrier
分子名称: Digitonin, Reduced folate transporter,Soluble cytochrome b562
著者Wright, N.J, Fedor, J.G, Lee, S.-Y.
登録日2022-02-07
公開日2022-09-21
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
7TX6
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Cryo-EM structure of the human reduced folate carrier in complex with methotrexate
分子名称: Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562
著者Wright, N.J, Fedor, J.G, Lee, S.-Y.
登録日2022-02-07
公開日2022-09-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
1J56
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BU of 1j56 by Molmil
MINIMIZED AVERAGE STRUCTURE OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN: MODEL STRUCTURE INCORPORATING ACTIVE SITE CONTACTS
分子名称: BERYLLIUM TRIFLUORIDE ION, NITROGEN REGULATION PROTEIN NR(I)
著者Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E.
登録日2002-01-10
公開日2003-08-19
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain
Biochemistry, 42, 2003
8ET7
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Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET8
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Cryo-EM structure of the organic cation transporter 1 in complex with verapamil
分子名称: (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET9
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Cryo-EM structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium
分子名称: 1-methyl-4-phenylpyridin-1-ium, OCT2
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET6
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Cryo-EM structure of the organic cation transporter 1 in the apo state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
6NC6
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BU of 6nc6 by Molmil
Lipid II flippase MurJ, inward closed conformation
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Lipid II flippase MurJ, ...
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2018-12-10
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NC7
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BU of 6nc7 by Molmil
Lipid II flippase MurJ, inward open conformation
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, SULFATE ION
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
8DEP
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BU of 8dep by Molmil
Cryo-EM structure of the human reduced folate carrier, apo condition
分子名称: Digitonin, Reduced folate transporter,Soluble cytochrome b562
著者Wright, N.J, Fedor, J.G, Lee, S.-Y.
登録日2022-06-21
公開日2022-09-21
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
6NC8
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BU of 6nc8 by Molmil
Lipid II flippase MurJ, inward occluded conformation
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, PENTAETHYLENE GLYCOL, ...
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NC9
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BU of 6nc9 by Molmil
Lipid II flippase MurJ, outward-facing conformation
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, ...
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NR4
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BU of 6nr4 by Molmil
Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium
分子名称: Transient receptor potential cation channel subfamily M member 8
著者Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
登録日2019-01-22
公開日2019-02-20
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NR2
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Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2
分子名称: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8
著者Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
登録日2019-01-22
公開日2019-02-20
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
8E4O
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BU of 8e4o by Molmil
The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4N
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BU of 8e4n by Molmil
The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4L
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The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
分子名称: 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ...
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4Q
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BU of 8e4q by Molmil
The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.51 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4P
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Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state
分子名称: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4M
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BU of 8e4m by Molmil
The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
6OO5
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Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 4.2 A
分子名称: TRPV2, resiniferatoxin
著者Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
登録日2019-04-22
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
6OO3
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Cryo-EM structure of the C4-symmetric TRPV2/RTx complex in amphipol resolved to 2.9 A
分子名称: TRPV2, resiniferatoxin
著者Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
登録日2019-04-22
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
6OO4
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Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A
分子名称: TRPV2, resiniferatoxin
著者Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
登録日2019-04-22
公開日2019-05-29
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019

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