8E4Q

The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2

Summary for 8E4Q

Entry DOI	10.2210/pdb8e4q/pdb
EMDB information	27896
Descriptor	Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
Functional Keywords	trpm8, menthol receptor, cold receptor, cold sensor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
Biological source	Ficedula albicollis (Collared flycatcher)
Total number of polymer chains	4
Total formula weight	528359.89
Authors	Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (deposition date: 2022-08-18, release date: 2022-10-26)
Primary citation	Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378:eadd1268-eadd1268, 2022 Cited by PubMed: 36227998 DOI: 10.1126/science.add1268 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.51 Å)

Structure validation